The Combined Effects of Genetic Variation in the CNDP1 and CNDP2 Genes and Dietary Carbohydrate and Carotene Intake on Obesity Risk.

Q Agricultural and Biological Sciences Journal of Nutrigenetics and Nutrigenomics Pub Date : 2017-01-01 Epub Date: 2018-01-17 DOI:10.1159/000485798

Kimiko Yamakawa-Kobayashi, Eri Otagi, Yuya Ohhara, Toshinao Goda, Nobuhiko Kasezawa, Yasunari Kayashima

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引用次数: 8

Abstract

Background/aims: It is possible that carnosinase (CNDP1) and cellular nonspecific dipeptidase (CNDP2) have important roles in protecting cells and tissues against the damage of oxidative stress. Oxidative stress and subsequent inflammation are key factors in the development of common chronic metabolic diseases, such as obesity. We aimed to investigate the combined effects of genetic variations in CNDP1 and CNDP2 and dietary carbohydrate and carotene intake on obesity risk.

Methods: A total of 1,059 Japanese men were randomly selected from participants who visited a medical center for routine medical checkups. We analyzed the relationships between the genotypes of 4 single-nucleotide polymorphisms (SNPs) (rs12605520, rs7244647, rs4891558, and rs17089368) in the CNDP1/CNDP2 locus and body mass index or prevalence of obesity/overweight taking into account dietary carbohydrate and carotene intake.

Results: We found that 2 SNPs (rs7244647 in CNDP1 and rs4891558 in CNDP2) were associated with obesity risk. In addition, these associations were observed only in the group with high carbohydrate and low carotene intake but not in the group with low carbohydrate and high carotene intake.

Conclusions: Our findings indicate that the combination of genetic variations in CNDP1 and CNDP2 and dietary carbohydrate/carotene intake modulate obesity risk.

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CNDP1和CNDP2基因遗传变异与膳食碳水化合物和胡萝卜素摄入量对肥胖风险的综合影响

背景/目的:肌肽酶(CNDP1)和细胞非特异性二肽酶(CNDP2)可能在保护细胞和组织免受氧化应激损伤中发挥重要作用。氧化应激和随后的炎症是常见慢性代谢性疾病(如肥胖)发展的关键因素。我们的目的是研究CNDP1和CNDP2基因变异以及膳食碳水化合物和胡萝卜素摄入量对肥胖风险的综合影响。方法:从到医疗中心进行常规体检的参与者中随机选出1,059名日本男性。我们分析了CNDP1/CNDP2位点的4个单核苷酸多态性(rs12605520、rs7244647、rs4891558和rs17089368)基因型与体重指数或肥胖/超重患病率之间的关系，并考虑了饮食中碳水化合物和胡萝卜素的摄入量。结果:我们发现2个snp (CNDP1中的rs7244647和CNDP2中的rs4891558)与肥胖风险相关。此外，这些关联仅在高碳水化合物和低胡萝卜素摄入组中观察到，而在低碳水化合物和高胡萝卜素摄入组中没有观察到。结论:我们的研究结果表明，CNDP1和CNDP2的遗传变异和饮食中碳水化合物/胡萝卜素的摄入共同调节肥胖风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrigenetics and Nutrigenomics GENETICS & HEREDITY-NUTRITION & DIETETICS

CiteScore

1.86

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The emerging field of nutrigenetics and nutrigenomics is rapidly gaining importance, and this new international journal has been established to meet the needs of the investigators for a high-quality platform for their research. Endorsed by the recently founded "International Society of Nutrigenetics/Nutrigenomics", the ‘Journal of Nutrigenetics and Nutrigenomics’ welcomes contributions not only investigating the role of genetic variation in response to diet and that of nutrients in the regulation of gene expression, but is also open for articles covering all aspects of gene-environment interactions in the determination of health and disease.