{"title":"The Role of Exercise and Hyperlipidaemia in Breast Cancer Progression.","authors":"Linda A Buss, Gabi U Dachs","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Exercise reduces the risk of breast cancer development and improves survival in breast cancer patients. However, the underlying mechanisms of this protective effect remain to be fully elucidated. It is unclear whether exercise can attenuate or modify the pro-tumour effects of obesity and related conditions, such as hyperlipidaemia. This review summarises how hyperlipidaemia and exercise contribute to or reduce breast cancer risk and progression, respectively, and highlights the possible mechanisms behind each. In particular, the effects of exercise and hyperlipidaemia on the immune microenvironment of tumours is analysed. The potential value of commonly investigated circulating factors as exercise-modulated, prognostic biomarkers is also discussed. We propose that exercise may alleviate some of the pro-tumorigenic effects of hyperlipidaemia through the reduction of blood lipid levels and modulation of cytokine release to induce beneficial changes in the tumour microenvironment.</p>","PeriodicalId":50468,"journal":{"name":"Exercise Immunology Review","volume":"24 ","pages":"10-25"},"PeriodicalIF":3.5000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exercise Immunology Review","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Exercise reduces the risk of breast cancer development and improves survival in breast cancer patients. However, the underlying mechanisms of this protective effect remain to be fully elucidated. It is unclear whether exercise can attenuate or modify the pro-tumour effects of obesity and related conditions, such as hyperlipidaemia. This review summarises how hyperlipidaemia and exercise contribute to or reduce breast cancer risk and progression, respectively, and highlights the possible mechanisms behind each. In particular, the effects of exercise and hyperlipidaemia on the immune microenvironment of tumours is analysed. The potential value of commonly investigated circulating factors as exercise-modulated, prognostic biomarkers is also discussed. We propose that exercise may alleviate some of the pro-tumorigenic effects of hyperlipidaemia through the reduction of blood lipid levels and modulation of cytokine release to induce beneficial changes in the tumour microenvironment.
期刊介绍：
Exercise Immunology Review (EIR) serves as the official publication of the International Society of Exercise and Immunology and the German Society of Sports Medicine and Prevention. It is dedicated to advancing knowledge in all areas of immunology relevant to acute exercise and regular physical activity. EIR publishes review articles and papers containing new, original data along with extensive review-like discussions. Recognizing the diverse disciplines contributing to the understanding of immune function, the journal adopts an interdisciplinary approach, facilitating the dissemination of research findings from fields such as exercise sciences, medicine, immunology, physiology, behavioral science, endocrinology, pharmacology, and psychology.
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