SNP Polymorphism in Genomes of CC320 Isolates of Streptococcuspneumoniae Resistant to Beta-Lactams.

Q4 Medicine Antibiotiki i Khimioterapiya Pub Date : 2016-01-01
I A Tzvetkova, M O Volkova, O S Kalinogorskaya, S S Belanov, V V Gostev, S V Sidorenko
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引用次数: 0

Abstract

Bioinformatic analysis of the data on the genome sequencing of the isolates of the Streptococcuspneumoniae clonal complex SS320 from the Russian Federation, as well as the data on SS320 isolates from public sources in the penicillin resistant isolates resulted in detection of 139 missense mutations in 45 genes. In addition to the mutations in the genes of the main penicillin-binding proteins (PSB - PBP1A, PBP2B and PBP2X) there was detected high frequency of mutations in the genes of the (division and cell wall) dcw-cluster, as well as in RegR protein belonging to the transcription regulators of the LacI/GaIR family. Development of resistance to beta-lactams in S.pneumoniae is defined not only by modification of the PSB, but also by adaptive changes in the metabolic pathways involved in the bacterial cell growth and division.

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耐β -内酰胺肺炎链球菌CC320株基因组SNP多态性研究
对来自俄罗斯联邦的肺炎链球菌克隆复合体SS320分离株的基因组测序数据以及来自青霉素耐药分离株的公共来源的SS320分离株的数据进行生物信息学分析,发现45个基因中有139个错义突变。除了主要的青霉素结合蛋白(PSB - PBP1A, PBP2B和PBP2X)基因突变外,还检测到(分裂和细胞壁)dcw簇基因的高频率突变,以及属于LacI/GaIR家族转录调节因子的RegR蛋白。肺炎链球菌对β -内酰胺类耐药的发展不仅取决于PSB的修饰,还取决于参与细菌细胞生长和分裂的代谢途径的适应性变化。
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来源期刊
Antibiotiki i Khimioterapiya
Antibiotiki i Khimioterapiya Medicine-Infectious Diseases
CiteScore
0.80
自引率
0.00%
发文量
46
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