The Effect of Antiviral Therapy on the Incidence of Bacterial Aggravations and Administration of Systemic Antibiotics in Patients with Acute Respiratory Viral Infections and Influenza (Results of International Cohort Observational Study).

Abstract

Objective: to evaluate the incidence of bacterial aggravations and antibiotics administration with analysis of effectiveness of antiviral therapy in ambulatory patients with acute viral respiratory infection (ARVI) and influenza.

Material and methods: International cohort open non-interventional .study <

Results: Bacterial aggravations were recorded in 8.3% cases, and-systemic antibiotics were prescribed by doctors in 9.3% cases. The incidence of bacterial aggravations and administration of systemic antibiotics increased proportionally to the age of patients, severity of disease, times of first visit to the doctor and the start of treatment. Prescription of Kagocel@ in the complex treatment of ARVI and influenza contributes to reduction of number of bacterial aggravations in 1.65 times (p<0.01) and decreases necessity of systemic antibiotic therapy in 1.51 times (p<0.01), which leads to better disease outcome at various therapy start times. Maximum efficiency and fewer treatment aggravations were recorded for working age patients.

Conclusions: Antiviral therapy has shown its effectiveness in the treatment of ARVI and influenza, its implementation leads to decrease of bacterial aggravations incidence.