Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems†

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Natural Product Reports Pub Date : 2023-01-01 DOI:10.1039/d2np00073c

Philippe Jeandet , Md. Sahab Uddin , Christophe Clément , Aziz Aziz , Cédric Jacquard , Haroon Khan , Muhammad Ajmal Shah , Essaid Ait Barka , Mattheos Koffas , Seyed Mohammad Nabavi , Eduardo Sobarzo-Sánchez , Jean-Hugues Renault

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引用次数: 5

Abstract

Though the iconic stilbene resveratrol and its related dimers constitute a top storyline in the field of natural product research, resveratrol oligomers (condensation >2) have been left aside despite their higher biological activity compared to that of the monomers. This situation largely results from the difficulty of getting them in sufficient quantities to enable evaluation of their biological properties in vivo. We present here a synthetic and critical analysis of the methods used for the production of high molecular-ordered stilbene oligomers of potential biomedical interest, gathering the most salient data regarding the approaches employed to prepare them by total synthesis, use of biomimetic approaches or through plant systems.

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生产用于研究其生物活性的高分子有序二苯乙烯低聚物：全合成、生物催化合成和植物系统生产†

尽管标志性的二苯乙烯-白藜芦醇及其相关二聚体构成了天然产物研究领域的顶级故事情节，但白藜芦醇低聚物（缩合物>；2）尽管与单体相比具有更高的生物活性，但仍被搁置一旁。这种情况在很大程度上是由于难以获得足够数量的它们来评估其体内生物特性。我们在这里对用于生产具有潜在生物医学意义的高分子有序二苯乙烯低聚物的方法进行了合成和批判性分析，收集了关于通过全合成、使用仿生方法或通过植物系统制备它们的方法的最显著数据。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.