{"title":"Facile synthesis of α-alkoxymethyltriphenylphosphonium iodides: new application of PPh<sub>3</sub>/I<sub>2</sub>.","authors":"Humaira Yasmeen Gondal, Zain Maqsood Cheema, Javid Hussain Zaidi, Sammer Yousuf, M Iqbal Choudhary","doi":"10.1186/s13065-018-0421-6","DOIUrl":null,"url":null,"abstract":"<p><p>An efficient one pot method for the synthesis of α-alkoxymethylphosphonium iodides is developed by using PPh<sub>3</sub>/I<sub>2</sub> combination at room temperature. Reaction conditions are found general to synthesize wide range of structurally variant alkoxymethylphosphonium iodides in high yield (70-91%). These new functionalized phosphonium salts are further used in stereoselective synthesis of vinyl ethers as well as in carbon homologation of aldehydes.</p>","PeriodicalId":9842,"journal":{"name":"Chemistry Central Journal","volume":"12 1","pages":"62"},"PeriodicalIF":0.0000,"publicationDate":"2018-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13065-018-0421-6","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry Central Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s13065-018-0421-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Chemistry","Score":null,"Total":0}
引用次数: 6
Abstract
An efficient one pot method for the synthesis of α-alkoxymethylphosphonium iodides is developed by using PPh3/I2 combination at room temperature. Reaction conditions are found general to synthesize wide range of structurally variant alkoxymethylphosphonium iodides in high yield (70-91%). These new functionalized phosphonium salts are further used in stereoselective synthesis of vinyl ethers as well as in carbon homologation of aldehydes.
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