{"title":"How T cells go rogue in the absence of Roquins.","authors":"Abdalla Akef, Stefan A Muljo","doi":"10.21037/ncri.2018.03.08","DOIUrl":null,"url":null,"abstract":"<p><p>Roquin-1 and Roquin-2 are RNA-binding proteins essential for modulating T cell activity. Indeed, Roquin dysfunction has been linked to autoimmunity in mice. Essig and colleagues (2017) determine their functions in Foxp3<sup>+</sup> T regulatory cells and uncover novel mechanisms of Roquin-mediated regulation of its target mRNAs (1).</p>","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.03.08","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Non-coding RNA investigation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21037/ncri.2018.03.08","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/4/23 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Roquin-1 and Roquin-2 are RNA-binding proteins essential for modulating T cell activity. Indeed, Roquin dysfunction has been linked to autoimmunity in mice. Essig and colleagues (2017) determine their functions in Foxp3+ T regulatory cells and uncover novel mechanisms of Roquin-mediated regulation of its target mRNAs (1).
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