Whole-Genome Sequencing and Annotation of a Drug-Resistant Extrapulmonary Clinical Isolate of Beijing Genotype Mycobacterium tuberculosis from Pune, India.

Swarupa M Hatolkar, Rabindra N Misra, Rajesh Mahato, Savita Jadhav
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引用次数: 1

Abstract

Whole-genome sequencing has emerged as a powerful tool to map genetic diversity among Mycobacterium tuberculosis isolates and identify the genomic signatures associated with drug resistance, pathogenesis, and disease transmission. Isolate LJ319 of the Mycobacterium tuberculosis complex (MTC)-Beijing genotype circulating in Maharashtra, India, which was obtained from the cerebrospinal fluid (CSF) of an immunocompetent patient, was subjected to whole-genome sequencing.

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印度浦那北京基因型结核分枝杆菌肺外临床耐药分离株的全基因组测序和注释。
全基因组测序已成为绘制结核分枝杆菌分离株遗传多样性和鉴定与耐药性、发病机制和疾病传播相关的基因组特征的有力工具。对印度马哈拉施特拉邦流行的结核分枝杆菌复合体(MTC)北京基因型分离物LJ319进行了全基因组测序,该分离物来自一名免疫正常患者的脑脊液。
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