[DEPENDENCE OF LEVEL OF MYELOPEROXIDASE OF PLASMA OF BLOOD ON FUNCTIONAL STATE OF NEUTROPHILS AT ACUTE INFARCT OF MYOCARDIUM.]

T I Gavrilenko, N O Ryzhkova, O M Parkhomenko
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Abstract

The purpose of this work was to define dependence of maintenance of myeloperoxidase (MPO) in plasma of blood of patients by the acute infarct of myocardium from the state of oxygen metabolism of neutrophils, which was estimated on activity of myeloperoxidases, superoxid-anion and catalase in cells and on maintenance by peroxigens. 19 is inspected practically healthy volunteers and 56 patients with the the acute infarct of myocardium. The got results testify that maintenance of MPO in plasma of blood of patients with acute infarct of myocardium depends on the functional state of neutrophils, which, in its turn, is related to the clinical features of patients. Low maintenance is associated exceptionally with low activity of MPO of neutrophils, and also other oxygen radicals. High maintenance of MPO in plasma accompanied low or high activity of MPO of neutrophils and is pathognomonic for patients with the acute infarct of myocardium.

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急性心肌梗死时血浆髓过氧化物酶水平与中性粒细胞功能状态的关系
本研究的目的是确定急性心肌梗死患者血浆中髓过氧化物酶(MPO)维持依赖于中性粒细胞的氧代谢状态,中性粒细胞的氧代谢状态由细胞中髓过氧化物酶、超氧阴离子和过氧化氢酶的活性以及过氧物质的维持来估计。实际健康志愿者19例,急性心肌梗死患者56例。结果表明,急性心肌梗死患者血浆中MPO的维持取决于中性粒细胞的功能状态,而中性粒细胞的功能状态又与患者的临床特征有关。低维持与中性粒细胞和其他氧自由基的MPO活性低异常相关。血浆中MPO的高维持伴随着中性粒细胞MPO的低或高活性,是急性心肌梗死患者的病理特征。
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