[EFFECT OF L-ARGININE - NO ON PROOXIDANT-ANTIOXIDANT BALANCE IN ERYTHROCYTES OF RATS UNDER ALCOHOL INTOXICATION.]

Abstract

It was shown changes in the activity of antioxidant enzymes (superoxide dismutase, catalase) and NO-synthase (NOS), in the content. of stable metabolic products of nitric oxide and levels of lipid peroxidation products in erythrocytes of rats under alcoholic intoxication. It was shown that animals with alcohol intoxication under of the admission of the main substrate NOS - L-arginine activity of antioxidant protection enzymes was increased in twice on the fond of TBA-positive products decrease contents. Established in hemolisate red blood cells in rats with alcohol inrotoxication value of total NOS activity decreases by 65% compared to control. Not selective inhibitor Nto-nitro-L-arginine methyl ester (L-NAME), which is a structural analog of L-arginine, reduced output level of total NOS activity by 23.4% in the control and 25% under conditions of pathology. The consumption of rats L-arginine NOS total activity increased in the two study groups. The results testify that L-arginine has antioxidant properties, whereas L-NAME exerts a slightly stabilizing influence.