[REDUCED RESPONSE OF NATURAL KILLER LYMPHOCYTES TO TOLL-LIKE RECEPTOR 3 STIMULATION IN CHILDREN WITH RECURRENT INFECTIONS.]

D V Osypchuk, V P Chernyshov, L I Chernysheva, N P Kissel, B V Dons'koi, I M Matvienko, V P Rodionov, Y Ua Makovs'ka
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引用次数: 3

Abstract

In this study, we examined the activation of natural killer(NK)-lymphocytes mediated by Toll-like receptor 3(TLR3), in the group of children with recurrent infections and the group of children with invasive bacterial infections. We examined level of CD69 (marker, of activation) expression on NK - lymphocytes after incubation with TLR3 ligand. There was a significant decrease in the level of an activation marker - 36,3±4,4% in the group of children with recurrent infections, compared with a control group of healthy children (56,5±4,9%) and the group of children with invasive bacterial infections (55,9±4,4%). Also, decreased was an activation potential of NK-lymphocytes - 24,9±L4,5% which was calculated as the difference between the percentage of CD69+ NK - lymphocytes after incubation and spontaneous value (without the addition of activator). There were no correlations between markers of TLR3 mediated activation of NK-cells and the age. Thus, the ability to activate NK - lymphocyte mediated by TLR3, independent of age and reduced in the group of children with recurrent infections. Reduced activation of NK-lymphocytes may contribute to increased susceptibility to viral infections and bacterial complications.

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[反复感染儿童自然杀伤淋巴细胞对toll样受体3刺激的反应降低]
在本研究中,我们检测了复发性感染儿童组和侵袭性细菌感染儿童组中toll样受体3(TLR3)介导的自然杀伤细胞(NK)-淋巴细胞的激活情况。我们检测了TLR3配体孵育后NK淋巴细胞上CD69(激活标记物)的表达水平。与健康儿童对照组(56,5±4,9%)和侵袭性细菌感染儿童组(55,9±4,4%)相比,复发性感染儿童组的激活标志物水平显著降低(36,3±4,4%)。NK-淋巴细胞活化电位降低- 24.9±4.5%,这是由孵育后CD69+ NK-淋巴细胞百分比与自发值(未添加激活剂)的差异计算的。TLR3介导的nk细胞活化标志物与年龄无相关性。因此,在反复感染的儿童中,TLR3介导的NK淋巴细胞激活能力与年龄无关,且降低。nk淋巴细胞活化降低可能导致对病毒感染和细菌并发症的易感性增加。
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