Mao-xu Ge, Ju-xian Wang, Rong-guang Shao, Hong-wei He
{"title":"[Advances in studies of ileal apical sodium-dependent bile acid transporter].","authors":"Mao-xu Ge, Ju-xian Wang, Rong-guang Shao, Hong-wei He","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Bile acids play critical roles in the regulation of metabolism and absorption of lipids. The ileal\napical sodium-dependent bile acid transporter (ASBT) located at the enterocyte brush border is responsible for\nthe reuptake of bile acids and the maintenance of bile acid homeostasis. Recently, a number of investigations\nhave been made concerning the regulation and control of ASBT and the relationship between ASBT and intestinal\ninflammation, tumorigenesis, diabetes mellitus and hyperlipemia, which suggests ASBT as a potential therapeutic\ntarget of these diseases. In this review, advances in the study of above-mentioned issues were summarized.</p>","PeriodicalId":35924,"journal":{"name":"药学学报","volume":"52 2","pages":"189-97"},"PeriodicalIF":0.0000,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"药学学报","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Bile acids play critical roles in the regulation of metabolism and absorption of lipids. The ileal
apical sodium-dependent bile acid transporter (ASBT) located at the enterocyte brush border is responsible for
the reuptake of bile acids and the maintenance of bile acid homeostasis. Recently, a number of investigations
have been made concerning the regulation and control of ASBT and the relationship between ASBT and intestinal
inflammation, tumorigenesis, diabetes mellitus and hyperlipemia, which suggests ASBT as a potential therapeutic
target of these diseases. In this review, advances in the study of above-mentioned issues were summarized.
药学学报Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.20
自引率
0.00%
发文量
0
期刊介绍：
Acta Pharmaceutica Sinica B (APSB) is a bimonthly English peer-reviewed online journal in ScienceDirect, which publishes significant original research articles, communications and high quality reviews of recent advances. APSB encourages submissions from all areas of pharmaceutical sciences, including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
APSB is a part of the series Acta Pharmaceutica Sinica, which was founded in 1953. The journal is co-published by Elsevier B.V., in association with the Institute of MateriaMedica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.
分享
京公网安备 11010802042870号
京ICP备2023020795号-1
求助内容：
应助结果提醒方式：
扫码关注我们
