{"title":"[Effects of metoprolol or/and pravastatin on the pharmacokinetics of metformin in rats].","authors":"Yan-rong Ma, Yan-fang Wu, Ying-qin Duan, Guo-qiang Zhang, Xin-an Wu","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>This study investigates the effects of metoprolol (METO) or/and pravastatin (PRAV) on the\npharmacokinetics of metformin (METF) in rats. Twenty-eight male SD rats were divided into METF group,\nMETF+METO group, METF+PRAV group and METF+METO+PRAV group. Blood samples were collected\nat 10, 20, 40, 60, 90, 120, 180, 240, 360, 480 and 600 min after oral administration of metformin, and\nconcentration of metformin in plasma was determined by HPLC. Compared to the METF group, Cmax of\nmetformin was significantly decreased (P < 0.01) and MRT0−t , t1/2 and V were significantly increased in\nthe METF+METO group; t1/2 was significantly decreased in the METF+PRAV group; Cmax was significantly\ndecreased and MRT0−t was significantly increased in the METF+METO+PRAV group. Compared to the\nMETF+METO group, MRT0−t of metformin was significantly decreased in the METF+METO+PRAV group.\nCompared to the METF+PRAV group, Cmax of metformin was significantly decreased (P < 0.01), and\nMRT0−t , t1/2 and V were significantly increased in the METF+METO+PRAV group. There exist multiple\ndrug interactions of metformin, metoprolol and pravastatin in rats.</p>","PeriodicalId":35924,"journal":{"name":"药学学报","volume":"52 2","pages":"253-7"},"PeriodicalIF":0.0000,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"药学学报","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
This study investigates the effects of metoprolol (METO) or/and pravastatin (PRAV) on the
pharmacokinetics of metformin (METF) in rats. Twenty-eight male SD rats were divided into METF group,
METF+METO group, METF+PRAV group and METF+METO+PRAV group. Blood samples were collected
at 10, 20, 40, 60, 90, 120, 180, 240, 360, 480 and 600 min after oral administration of metformin, and
concentration of metformin in plasma was determined by HPLC. Compared to the METF group, Cmax of
metformin was significantly decreased (P < 0.01) and MRT0−t , t1/2 and V were significantly increased in
the METF+METO group; t1/2 was significantly decreased in the METF+PRAV group; Cmax was significantly
decreased and MRT0−t was significantly increased in the METF+METO+PRAV group. Compared to the
METF+METO group, MRT0−t of metformin was significantly decreased in the METF+METO+PRAV group.
Compared to the METF+PRAV group, Cmax of metformin was significantly decreased (P < 0.01), and
MRT0−t , t1/2 and V were significantly increased in the METF+METO+PRAV group. There exist multiple
drug interactions of metformin, metoprolol and pravastatin in rats.
药学学报Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.20
自引率
0.00%
发文量
0
期刊介绍：
Acta Pharmaceutica Sinica B (APSB) is a bimonthly English peer-reviewed online journal in ScienceDirect, which publishes significant original research articles, communications and high quality reviews of recent advances. APSB encourages submissions from all areas of pharmaceutical sciences, including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
APSB is a part of the series Acta Pharmaceutica Sinica, which was founded in 1953. The journal is co-published by Elsevier B.V., in association with the Institute of MateriaMedica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.
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