{"title":"[Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency].","authors":"Shu-fen He, Wen-zheng Ju, Hao-bin Hu, Li-jing Zhu, Qian Zhang, Guo-liang Dai","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>This study was designed to explore the impact of depression on kidney-yang deficiency in rats.\nRats were repeatedly injected with hydrocortisone for 21 days to establish the depression model with kidneyyang\ndeficiency. Tolbutamide, chlorzoxazone, theophylline, midazolam, omeprazole and dextromethorphan\nwere used as substrates of CYP2C6, CYP2E1, CYP1A2, CYP3A2, CYP2D1, and CYP2D2 to test the depression\nimpact on drug metabolism. Plasma concentrations of six CYP450 were determined by LC-MS/MS and used as\npharmacokinetic parameters. Consequently, metabolism of theophylline, chlorzoxazone and tolbutamide were\naccelerated significantly in the model relative to the control (P < 0.01), but dextromethorphan, omeprazole and\nmidazolam did not exhibit a significant difference. The present study suggests that depression with kidneyyang\ndeficiency had a strong induction of CYP2E1 and moderate induction of CYP1A2, CYP2C6 in the rat\nmodel.</p>","PeriodicalId":35924,"journal":{"name":"药学学报","volume":"52 2","pages":"258-63"},"PeriodicalIF":0.0000,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"药学学报","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
This study was designed to explore the impact of depression on kidney-yang deficiency in rats.
Rats were repeatedly injected with hydrocortisone for 21 days to establish the depression model with kidneyyang
deficiency. Tolbutamide, chlorzoxazone, theophylline, midazolam, omeprazole and dextromethorphan
were used as substrates of CYP2C6, CYP2E1, CYP1A2, CYP3A2, CYP2D1, and CYP2D2 to test the depression
impact on drug metabolism. Plasma concentrations of six CYP450 were determined by LC-MS/MS and used as
pharmacokinetic parameters. Consequently, metabolism of theophylline, chlorzoxazone and tolbutamide were
accelerated significantly in the model relative to the control (P < 0.01), but dextromethorphan, omeprazole and
midazolam did not exhibit a significant difference. The present study suggests that depression with kidneyyang
deficiency had a strong induction of CYP2E1 and moderate induction of CYP1A2, CYP2C6 in the rat
model.
药学学报Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.20
自引率
0.00%
发文量
0
期刊介绍：
Acta Pharmaceutica Sinica B (APSB) is a bimonthly English peer-reviewed online journal in ScienceDirect, which publishes significant original research articles, communications and high quality reviews of recent advances. APSB encourages submissions from all areas of pharmaceutical sciences, including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
APSB is a part of the series Acta Pharmaceutica Sinica, which was founded in 1953. The journal is co-published by Elsevier B.V., in association with the Institute of MateriaMedica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.
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