[Recent Progress and Practical Prospects for the HIV-1 Capsid Structure].

Abstract

The human immunodeficiency virus type 1(HIV-1)has spread globally and often exhibits antiviral resistance. Therefore, there is an ongoing need for the development of novel, highly efficient antiretroviral drugs with low toxicity. The capsid protein(CA),which is composed of an N-terminal domain(NTD)and C-terminal domain(CTD),plays an important role in the process of HIV-1assembly and maturation. In recent years, the structure of capsid protein has been solved. In this article, we summarizes the spatial structure of the HIV-1capsid protein determined by X-ray crystallography, and describe the structural characteristics of the NTD-NTD,NTD-CTD and CTD-CTD interfaces. This article summarizes the antiviral approaches targeting CA and expounds a new strategy in combination with CRISPR/Cas9 gene editing technology.