[Research Progress in Virus Infection Altering Cellular Glucose Metabolism].

Shiwei Wu, Xiaozhe Fu, Qiang Lin, Lihui Liu, Hongru Liang, Zhibin Huang, Ningqiu Li
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Abstract

Viruses "hijack" cellular metabolism to complete their proliferation. Glucose is an important source of energy and carbon in the synthesis of precursor molecules in host cells, and its metabolism is regulated dramatically during virus infection. Here, we reviewed the mechanism of virus infection that alters glucose transport, expression of glucose metabolism-related genes (glycolysis, pentose phosphate pathway, gluconeogenesis) in cells, as well as islet cells and insulin receptors. It provides references for study of virus-altering cellular glucose metabolism.

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病毒感染改变细胞糖代谢的研究进展
病毒“劫持”细胞代谢来完成它们的增殖。葡萄糖是宿主细胞前体分子合成的重要能量和碳源,其代谢在病毒感染过程中受到显著调节。本文综述了病毒感染改变细胞中葡萄糖转运、糖代谢相关基因(糖酵解、戊糖磷酸途径、糖异生)表达以及胰岛细胞和胰岛素受体的机制。为病毒改变细胞糖代谢的研究提供参考。
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