Benzoyl Peroxide Inhibits Quorum Sensing and Biofilm Formation by Gardnerella vaginalis 14018.

Q2 Medicine Infectious Diseases in Obstetrics and Gynecology Pub Date : 2018-07-02 eCollection Date: 2018-01-01 DOI:10.1155/2018/1426109

Ammar Algburi, Saskia Zehm, Victoria Netrebov, Richard Weeks, Konstantin Zubovskiy, Michael L Chikindas

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Abstract

Infection recurrence and antibiotic resistance of bacterial vaginosis-associated pathogenic biofilms underline the need for novel and effective treatment strategies. In this study, we evaluated the antimicrobial, antibiofilm, and quorum sensing inhibitory effects of benzoyl peroxide and salicylic acid against Gardnerella vaginalis ATCC 14018, the predominant pathogen of bacterial vaginosis. While the highest tested concentrations of 250 and 125 μg/mL for both compounds were not sufficient in completely inhibiting the growth of G. vaginalis ATCC 14018, they did prevent biofilm formation by inhibiting the bacterial quorum sensing system in the pathogen. To our knowledge, this report is the first evidence that benzoyl peroxide can have a quorum sensing-mediated biofilm controlling effect, as demonstrated using subinhibitory concentrations of this compound in order to reduce the cost, dosage, and negative side effects associated with current antimicrobial treatments.

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过氧化苯甲酰可抑制阴道加德纳菌 14018 的定量感应和生物膜形成。

细菌性阴道病相关致病生物膜的感染复发和抗生素耐药性凸显了新型有效治疗策略的必要性。在这项研究中，我们评估了过氧化苯甲酰和水杨酸对阴道加德纳菌 ATCC 14018（细菌性阴道病的主要病原体）的抗菌、抗生物膜和法定量感应抑制作用。虽然这两种化合物的最高测试浓度（250 和 125 μg/mL ）不足以完全抑制阴道加德纳菌 ATCC 14018 的生长，但它们确实通过抑制病原体中的细菌法定人数感应系统防止了生物膜的形成。据我们所知，这份报告首次证明了过氧化苯甲酰具有由法定人数感应系统介导的生物膜控制效果，使用亚抑制浓度的这种化合物可以降低成本、用量，并减少与当前抗菌治疗相关的负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious Diseases in Obstetrics and Gynecology Medicine-Obstetrics and Gynecology

CiteScore

3.80

自引率

0.00%

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审稿时长

12 weeks

期刊介绍： Infectious Diseases in Obstetrics and Gynecology aims to disseminate new and important information to clinicians and other health care providers, scientists, and researchers involved in the study or treatment of infectious diseases, especially those affecting the female patient. Its ultimate aim is to advance knowledge and encourage research, thereby improving the prevention or diagnosis and treatment of patients affected by such diseases.