Stress of Strains: Inbred Mice in Liver Research.

Q2 Biochemistry, Genetics and Molecular Biology Gene expression Pub Date : 2018-12-14 Epub Date: 2018-08-09 DOI:10.3727/105221618X15337408678723
Arlin B Rogers
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引用次数: 19

Abstract

Inbred mice are the most popular animals used for in vivo liver research. These mice are genetically defined, readily available, less expensive to maintain than larger animals, and enjoy a broad array of commercial reagents for scientific characterization. C57BL/6 mice are the most commonly used strain. However, other strains discussed, including BALB/c, C3H, A/J, and FVB/N, may be better suited to a particular disease model or line of investigation. Understanding the phenotypes of different inbred mouse strains facilitates informed decision making during experimental design. Model systems influenced by strain-dependent phenotype include tissue regeneration, drug-induced liver injury (DILI; e.g., acetaminophen), fibrosis (e.g., carbon tetrachloride, CCl₄), Fas-induced apoptosis, cholestasis, alcohol-induced liver disease and cirrhosis, nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH), and hepatocellular carcinoma (HCC). Thoughtful consideration of the strengths and weaknesses of each inbred strain in a given model system will lead to more robust data and a clearer understanding of translational relevance to human liver disease.

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菌株应激:近交系小鼠肝脏研究。
近交系小鼠是体内肝脏研究中最常用的动物。这些老鼠在基因上是确定的,容易获得,比大型动物更便宜,并且享受广泛的商业试剂来进行科学表征。C57BL/6小鼠是最常用的菌株。然而,所讨论的其他菌株,包括BALB/c、C3H、A/J和FVB/N,可能更适合于特定的疾病模型或研究方向。了解不同近交系小鼠株的表型有助于在实验设计过程中做出明智的决策。受菌株依赖表型影响的模型系统包括组织再生、药物性肝损伤(DILI;例如,对乙酰氨基酚),纤维化(例如,四氯化碳,CCl₄),fas诱导的细胞凋亡,胆汁淤积,酒精诱导的肝病和肝硬化,非酒精性脂肪性肝病和脂肪性肝炎(NAFLD/NASH),以及肝细胞癌(HCC)。对给定模型系统中每个近交系的优势和劣势进行深思熟虑的考虑,将导致更可靠的数据,并更清楚地了解与人类肝脏疾病的转化相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gene expression
Gene expression 生物-生物工程与应用微生物
CiteScore
3.80
自引率
0.00%
发文量
3
审稿时长
>12 weeks
期刊介绍: Gene Expression, The Journal of Liver Research will publish articles in all aspects of hepatology. Hepatology, as a research discipline, has seen unprecedented growth especially in the cellular and molecular mechanisms of hepatic health and disease, which continues to have a major impact on understanding liver development, stem cells, carcinogenesis, tissue engineering, injury, repair, regeneration, immunology, metabolism, fibrosis, and transplantation. Continued research and improved understanding in these areas will have a meaningful impact on liver disease prevention, diagnosis, and treatment. The existing journal Gene Expression has expanded its focus to become Gene Expression, The Journal of Liver Research to meet this growing demand. In its revised and expanded scope, the journal will publish high-impact original articles, reviews, short but complete articles, and special articles (editorials, commentaries, opinions) on all aspects of hepatology, making it a unique and invaluable resource for readers interested in this field. The expanded team, led by an Editor-in-Chief who is uniquely qualified and a renowned expert, along with a dynamic and functional editorial board, is determined to make this a premier journal in the field of hepatology.
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