{"title":"Potential Epigenetic Modifiers Targeting the Alteration of Methylation in Colorectal Cancer","authors":"Abdeslam Jaafari","doi":"10.14218/ge.2023.00039s","DOIUrl":"https://doi.org/10.14218/ge.2023.00039s","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"106 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Todosenko, K. Yurova, O. Khaziakhmatova, M. Vulf, M. Bograya, Pavel Ivanov, Larisa Litvinova
{"title":"(Epi)genetic Aspects of Metabolic Syndrome Pathogenesis in Relation to Brain-derived Neurotrophic Factor Expression: A Review","authors":"N. Todosenko, K. Yurova, O. Khaziakhmatova, M. Vulf, M. Bograya, Pavel Ivanov, Larisa Litvinova","doi":"10.14218/ge.2023.00202","DOIUrl":"https://doi.org/10.14218/ge.2023.00202","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michel Planat, M. Amaral, David Chester, F. Fang, Raymond Aschheim, K. Irwin
{"title":"Group Theory of Messenger RNA Metabolism and Disease","authors":"Michel Planat, M. Amaral, David Chester, F. Fang, Raymond Aschheim, K. Irwin","doi":"10.14218/ge.2023.00079","DOIUrl":"https://doi.org/10.14218/ge.2023.00079","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"685 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140479616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detailed Stability and Unfolding Study of Mycobacterium Global Transcription Regulator Protein","authors":"Abinit Saha, Devlina Chakravarty, Soumyananda Chakraborti","doi":"10.14218/ge.2023.00043","DOIUrl":"https://doi.org/10.14218/ge.2023.00043","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138973284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyed Mohammad Hadi Safaei, M. Mohammadabadi, Borhan Moradi, Oleksandr Kalashnyk, N. Klopenko, Olena Babenko, Oleksandr Oleksandrovich Borshch, V. Afanasenko
{"title":"Role of Fennel (Foeniculum vulgare) Seed Powder in Increasing Testosterone and IGF1 Gene Expression in the Testis of Lamb","authors":"Seyed Mohammad Hadi Safaei, M. Mohammadabadi, Borhan Moradi, Oleksandr Kalashnyk, N. Klopenko, Olena Babenko, Oleksandr Oleksandrovich Borshch, V. Afanasenko","doi":"10.14218/ge.2023.00020","DOIUrl":"https://doi.org/10.14218/ge.2023.00020","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"63 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138595493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypoxia-inducible factor-1 alpha (HIF-1α) is usually regarded as a core regulator of hypoxic response. Persistent inflammation and impaired wound healing are common manifestations of diabetic foot ulcer (DFU). In normal wounds, HIF-1α and its related regulatory molecules, such as vascular endothelial growth factor and inducible nitric oxide synthase, are activated by hypoxia signals, which in turn promote wound healing. However, abnormal regulation of the HIF-1α signaling pathway by hyperglycemia leads to impaired wound healing in DFU. In this review, we highlight the tissue-specific and stage-specific effects of the HIF-1α signaling pathway in DFU. In the early stage of DFU, HIF-1α in inflammatory cells is over-upregulated by hyperglycemia, causing the activation of nuclear factor-κB and the inducible nitric oxide synthase-mediated pro-inflammatory signaling pathway, leading to sustained inflammation, which is deleterious. In the late stage of DFU, HIF-1α in endothelial cells and keratinocytes is inhibited by hyperglycemia, which leads to the downregulation of vascular endothelial growth factor expression, resulting in insufficient angiogenesis and difficult healing at the wound site. In this review, we discuss recent advances in the knowledge of the HIF-1α signaling pathway and the key targeted molecules in impaired wound healing of DFU. We also summarize the drugs currently in clinical trials that target HIF-1α or its downstream molecules, recapitulate current gaps in our knowledge, and propose rational therapeutic strategies for DFU based on the action characteristics of HIF-1α.
{"title":"Hypoxia-inducible Factor-1α in Diabetic Foot Ulcers: Plain but Not Simple","authors":"Xinmeng Zhou, Daojiang Yu, Xiaodong Sun, Wei Huang, Yong Xu, Changlong Li, Yuanyuan Zhang","doi":"10.14218/ge.2023.00051","DOIUrl":"https://doi.org/10.14218/ge.2023.00051","url":null,"abstract":"Hypoxia-inducible factor-1 alpha (HIF-1α) is usually regarded as a core regulator of hypoxic response. Persistent inflammation and impaired wound healing are common manifestations of diabetic foot ulcer (DFU). In normal wounds, HIF-1α and its related regulatory molecules, such as vascular endothelial growth factor and inducible nitric oxide synthase, are activated by hypoxia signals, which in turn promote wound healing. However, abnormal regulation of the HIF-1α signaling pathway by hyperglycemia leads to impaired wound healing in DFU. In this review, we highlight the tissue-specific and stage-specific effects of the HIF-1α signaling pathway in DFU. In the early stage of DFU, HIF-1α in inflammatory cells is over-upregulated by hyperglycemia, causing the activation of nuclear factor-κB and the inducible nitric oxide synthase-mediated pro-inflammatory signaling pathway, leading to sustained inflammation, which is deleterious. In the late stage of DFU, HIF-1α in endothelial cells and keratinocytes is inhibited by hyperglycemia, which leads to the downregulation of vascular endothelial growth factor expression, resulting in insufficient angiogenesis and difficult healing at the wound site. In this review, we discuss recent advances in the knowledge of the HIF-1α signaling pathway and the key targeted molecules in impaired wound healing of DFU. We also summarize the drugs currently in clinical trials that target HIF-1α or its downstream molecules, recapitulate current gaps in our knowledge, and propose rational therapeutic strategies for DFU based on the action characteristics of HIF-1α.","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"44 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136234521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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