{"title":"Retromer and Its Role in Regulating Signaling at Endosomes.","authors":"Matthew N J Seaman","doi":"10.1007/978-3-319-96704-2_5","DOIUrl":null,"url":null,"abstract":"<p><p>The retromer complex is a key element of the endosomal protein sorting machinery being involved in trafficking of proteins from endosomes to the Golgi and also endosomes to the cell surface. There is now accumulating evidence that retromer also has a prominent role in regulating the activity of many diverse signaling proteins that traffic through endosomes and this activity has profound implications for the functioning of many different cell and tissue types from neuronal cells to cells of the immune system to specialized polarized epithelial cells of the retina. In this review, the protein composition of the retromer complex will be described along with many of the accessory factors that facilitate retromer-mediated endosomal protein sorting to detail how retromer activity contributes to the regulation of several distinct signaling pathways.</p>","PeriodicalId":20880,"journal":{"name":"Progress in molecular and subcellular biology","volume":"57 ","pages":"137-149"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-319-96704-2_5","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in molecular and subcellular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-319-96704-2_5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 12
Abstract
The retromer complex is a key element of the endosomal protein sorting machinery being involved in trafficking of proteins from endosomes to the Golgi and also endosomes to the cell surface. There is now accumulating evidence that retromer also has a prominent role in regulating the activity of many diverse signaling proteins that traffic through endosomes and this activity has profound implications for the functioning of many different cell and tissue types from neuronal cells to cells of the immune system to specialized polarized epithelial cells of the retina. In this review, the protein composition of the retromer complex will be described along with many of the accessory factors that facilitate retromer-mediated endosomal protein sorting to detail how retromer activity contributes to the regulation of several distinct signaling pathways.
期刊介绍：
Molecular biology has been providing an overwhelming amount of data on the structural components and molecular machineries of the cell and its organelles and the complexity of intra- and intercellular communication. The molecular basis of hereditary and acquired diseases is beginning to be unravelled, and profound new insights into development and evolutionary biology have been gained from molecular approaches. Progress in Molecular and Subcellular Biology summarises the most recent developments in this fascinating area of biology.
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