Salivary lactate dehydrogenase (LDH) as a tool for early diagnosis of oral cancer in individuals with Fanconi anemia

IF 0.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Medical hypotheses Pub Date : 2018-10-01 DOI:10.1016/j.mehy.2018.07.021

Talita Piassa Mafessoni, Carolina Eurich Mazur, José Miguel Amenábar

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引用次数: 6

Abstract

Currently one of the greater challenges is the diagnosis and treatment of cancer. Many studies address the genetic and metabolic aspects to support in early diagnosis and increase the survival of individuals at high risk. Individuals with Fanconi anemia can be included in this high risk group because they have a predisposition to develop head and neck cancer. The use of salivary enzymes as biomarkers to detect the changes in oral tissue at the initial phase seems viable, because saliva is easy to obtain, it moisture oral mucosa and cells metabolic compounds can be found on it. Due to the metabolic characteristics of the cancer cell, an increase in Lactate Dehydrogenase (LDH) may indicate a carcinogenesis process. The hypothesis of this study is to use of salivary LDH as a tool in the early diagnosis of oral cancer on a high risk group such as Fanconi anemia’s patients.

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唾液乳酸脱氢酶(LDH)作为范可尼贫血患者口腔癌早期诊断的工具

目前更大的挑战之一是癌症的诊断和治疗。许多研究解决了遗传和代谢方面的问题，以支持早期诊断和增加高危个体的生存率。范可尼贫血症患者可以被列入这一高风险群体，因为他们有患头颈癌的倾向。利用唾液酶作为生物标志物来检测口腔组织在初始阶段的变化似乎是可行的，因为唾液容易获得，它湿润口腔黏膜和细胞的代谢化合物可以在其上找到。由于癌细胞的代谢特性，乳酸脱氢酶(乳酸脱氢酶)的增加可能预示着癌变过程。本研究的假设是将唾液乳酸脱氢酶作为口腔癌高危人群如范可尼贫血患者早期诊断的工具。

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.