[Two New Abietane Type Diterpenes from Pinecones of Pinus griffithii].

中药材 Pub Date : 2016-06-01
Yu-mei Zhao, Jian-rong Luo, Wen-ji He, Si-wen Yang, Guang-Ming Liu, Zhen Zhang
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引用次数: 0

Abstract

Objective: To study the chemical constituents from the pinecones of Pinus griffithii.

Methods: The constituents were separated and purified with chromatographic methods,and spectroscopic analysis were employed for structural elucidation.

Results: Two new abietane type diterpenes and seven known compounds were isolated from the pinecones of Pinus griffithii,and were identified as 15-hydroxy-7α-methoxy-abiet-8,11,13-trien-18-oic acid( 1),7α,13-dihydroxy-podocarpane-8,11,13-trien-18-oic acid( 2),7,12,13,15-tetrahydroxy-abiet-8( 14)-en-18-oic acid( 3),7β,15-dihydroxy-abiet-8,11,13-trien-18-oic acid( 4),18-norabiet-8,11,13-trien-4,7,15-triol( 5),15-hydroxy-abiet-8,11,13-trien-18-oic acid( 6),7α-hydroxy-15-methoxy-abiet-8,11,13-trien-18-oic acid( 7),7α-hydroxypodocarpen-8( 14)-en-13-one-18-oic acid( 8), oleanolic acid( 9).

Conclusion: Compounds 1,2 are the new abietane type diterpene,and all compounds are isolated from this plant for first time.

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[两种新枞烷型二萜]。
目的:研究格里菲松松果的化学成分。方法:采用色谱法对药材进行分离纯化,并用波谱法对其结构进行解析。结果:两个新的松香烷型二萜和七个已知化合物分离的松果松果体griffithii,并被确认为15-hydroxy-7α-methoxy-abiet-8, 11日13-trien-18-oic酸(1)、7α,13-dihydroxy-podocarpane-8, 11日13-trien-18-oic酸(2)、7、12、13日15-tetrahydroxy-abiet-8 (14) -en-18-oic酸(3)、7β,15-dihydroxy-abiet-8, 11日13-trien-18-oic酸(4)、18-norabiet-8, 11日13-trien-4, 7日15-triol (5), 15-hydroxy-abiet-8, 11日13-trien-18-oic酸(6)、7α-hydroxy-15-methoxy-abiet-8, 11日13-trien-18-oic结论:化合物1、2为新发现的枞烷型二萜,均为首次从该植物中分离得到。
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期刊介绍: "Chinese Materia Medica" magazine was founded in 1978. It is a national-level academic journal of Chinese medicine science and technology approved by the State Science and Technology Commission and the Press and Publication Administration for public distribution at home and abroad. It is sponsored by the Chinese Materia Medica Information Center of the State Food and Drug Administration and is publicly distributed at home and abroad. It mainly reports on new technologies, new methods and new achievements in the production, scientific research and business management of Chinese medicine, and serves to promote the production and scientific and technological development of Chinese medicine, improve the output and quality of Chinese medicine, improve business management, and prosper the Chinese medicine industry.
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