Sally S Hassouna, Manal Y Tayel, Dalal M ElKaffash, Ahmed M Abdelhady, Eman H Elsayed
{"title":"MicroRNA155 Expression in Relation to BDCAF Scored Behçet's Disease in an Egyptian Patients' Sample.","authors":"Sally S Hassouna, Manal Y Tayel, Dalal M ElKaffash, Ahmed M Abdelhady, Eman H Elsayed","doi":"10.2174/1874312901812010115","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To discover the possibility of using microRNA155 (miRNA155) expression level as a biomarker of Behçet's Disease (BD) activity or remission.</p><p><strong>Methods: </strong>Thirty BD patients' white blood cells (WBCs) miRNA155 expression was measured and compared to WBCs miRNA155 expression in 15 healthy subjects. Assessment of disease activity was done using Behçet's Disease Current Activity Form (BDCAF).</p><p><strong>Results: </strong>miRNA155 expression significantly decreases with the increase of BD activity scored by BDCAF.</p><p><strong>Conclusion: </strong>Increased miRNA155 may be used as a biomarker of BD remission and thus in the disease follow up. There could be a prospect of treating the disease <i>via</i> microRNA 155 effect enhancement.</p>","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110073/pdf/","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Rheumatology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874312901812010115","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 5
Abstract
Objective: To discover the possibility of using microRNA155 (miRNA155) expression level as a biomarker of Behçet's Disease (BD) activity or remission.
Methods: Thirty BD patients' white blood cells (WBCs) miRNA155 expression was measured and compared to WBCs miRNA155 expression in 15 healthy subjects. Assessment of disease activity was done using Behçet's Disease Current Activity Form (BDCAF).
Results: miRNA155 expression significantly decreases with the increase of BD activity scored by BDCAF.
Conclusion: Increased miRNA155 may be used as a biomarker of BD remission and thus in the disease follow up. There could be a prospect of treating the disease via microRNA 155 effect enhancement.
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