[Comparative Study on Protection Effects of CCl4-Induced Acute Liver Injury of Different Prepared Products from Gardenia jasminoides Fruits in Rats].

中药材 Pub Date : 2016-07-01

Jian Shao, Guang-ming Luo, Ji-xiao Zhu, Ya-qin Yang, Yang-jing Luo, Yuan-jian Yuan

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引用次数: 0

Abstract

Objective: To provide the experimental evidence for the appropriate selection of the different prepared products from Gardenia jasminoides fruits by comparing their protection effects on carbon tetrachloride（ CCl4）-induced acute liver injury.

Methods: The activities of ALT,AST,ADA,LDH,ALP and contents of PA,TP,TBIL,DBIL,TBA in serum,the activities of SOD and the content of MDA in liver tissue were measured in acute liver injury rats by carbon tetrachloride. Also the pathological changes of liver tissues were examined under microscope.

Results: The biochemical indexes of AST,ALT,TBA,ADA,LDH and MDA were significantly improved in all groups of prepared products from Gardenia jasminoides fruits,but not SOD and ALP. The lesions of liver tissue had different degrees of reduction.

Conclusion: The different prepared products from Gardenia jasminoides fruits had the effects of liver protection. The nut of Gardeniae Fructus was superior to the peel in enzyme decreasing and liver protection. The crude was superior to the stir-cooked in enzyme decreasing and liver protection.

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[栀子果实不同制剂对ccl4致大鼠急性肝损伤保护作用的比较研究]。

目的:通过比较栀子果实不同炮制品对四氯化碳(CCl4)致急性肝损伤的保护作用，为合理选择栀子果实炮制品提供实验依据。方法:采用四氯化碳法测定急性肝损伤大鼠血清中ALT、AST、ADA、LDH、ALP活性及PA、TP、TBIL、DBIL、TBA含量，肝组织中SOD活性及MDA含量。并在显微镜下观察肝组织的病理变化。结果:栀子果制剂各组小鼠血清AST、ALT、TBA、ADA、LDH、MDA等生化指标均有显著改善，SOD、ALP无显著改善。肝组织病变有不同程度的缩小。结论:栀子果不同制剂均具有保肝作用。栀子果的降酶和保肝作用优于果皮。粗提物在降酶和保肝作用上优于炒熟物。

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来源期刊

中药材

自引率

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发文量

11364

期刊介绍： "Chinese Materia Medica" magazine was founded in 1978. It is a national-level academic journal of Chinese medicine science and technology approved by the State Science and Technology Commission and the Press and Publication Administration for public distribution at home and abroad. It is sponsored by the Chinese Materia Medica Information Center of the State Food and Drug Administration and is publicly distributed at home and abroad. It mainly reports on new technologies, new methods and new achievements in the production, scientific research and business management of Chinese medicine, and serves to promote the production and scientific and technological development of Chinese medicine, improve the output and quality of Chinese medicine, improve business management, and prosper the Chinese medicine industry.