EFFECT OF HYDROGEN SULPHIDE DONOR ON INTRAOCULAR PRESSURE IN RATS.

Abstract

It has been investigated the effect of a 1% solution of sodium hydrosulfide NaHS on intraocular pressure (IOP) in intact rats and during modeling them of ocular hypertension, using prolonged systemic administration of adrenaline. A single administration of hydrogen sulphide donor as drops into cavity of the eye has caused the hypotensive effect, which was pretty weak in the normotensive eyes and pronounced in the eyes with ocular hypertension. Long-term administration ofNaHS solution by the scheme, during administration of adrenaline as a model inductor, has largely prevented IOP rise. It done conclusion that hydrogen sulphide is involved in the regulation of eye hydrodynamics and maintaining normal levels of IOP.