Determination of Thirteen Trace and Toxic Elements in Urine Using Inductively Coupled Mass Spectrometry

Maria A. Velez-Quinones, Hanna Xu, Nhu Vo, Joanna M. Gaitens, Melissa A. McDiarmid, Michael R. Lewin-Smith, Frederick G. Strathmann
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引用次数: 8

Abstract

We developed and validated a method for the assessment of thirteen separate trace and toxic elements using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). Included elements were as follows: aluminum, chromium, manganese, iron, cobalt, nickel, copper, zinc, arsenic, molybdenum, cadmium, tungsten, and lead. The measurements of all elements in urine samples were conducted using ICAP-Q ICP-MS in a single method. The performance characteristics of the assay were determined according to clinical laboratory standards. The assay was linear in the concentration range of 1.0 to 1000.0 µg/liter for all elements. The method was precise and accurate with limits of quantitation of 1 µg/liter for chromium, manganese, cobalt, nickel, copper, cadmium, tungsten, and lead; 2 µg/liter for iron and arsenic; 5 µg/liter for aluminum; and 50 µg/liter for zinc. This method has successfully been used for the assessment of all thirteen elements included in urine and has been shown to be effective as a simple, precise, and sensitive analytical technique for biological monitoring of urine samples. © 2018 by John Wiley & Sons, Inc.

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电感耦合质谱法测定尿液中13种微量和有毒元素
我们开发并验证了一种使用电感耦合等离子体质谱(ICP-MS)评估13种不同痕量和有毒元素的方法。包括的元素如下:铝、铬、锰、铁、钴、镍、铜、锌、砷、钼、镉、钨和铅。采用ICAP-Q ICP-MS对尿样中所有元素进行单方法测定。根据临床实验室标准确定了该方法的性能特征。所有元素在1.0 ~ 1000.0µg/l浓度范围内呈线性关系。方法精密度高,对铬、锰、钴、镍、铜、镉、钨、铅的定量限为1µg/l;铁和砷2微克/升;5微克/升铝;锌为50微克/升。该方法已成功地用于评估尿液中包含的所有13种元素,并已被证明是一种简单、精确和敏感的尿液样本生物监测分析技术。©2018 by John Wiley &儿子,Inc。
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