Evaluation of the use of tranexamic acid in total knee arthroplasty

Revista Brasileira de Ortopedia (English Edition) Pub Date : 2018-11-01 DOI:10.1016/j.rboe.2018.09.008

Mariana Diana Chaves de Almeida , Rodrigo Pires e Albuquerque , Guilherme Mathias Palhares , Juliana Patrícia Chaves de Almeida , João Mauricio Barretto , Naasson Cavanellas

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引用次数: 3

Abstract

Objective

Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty.

Methods

101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate.

Results

Comparing the groups, there were statistically significant differences (p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion.

Conclusion

The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.

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氨甲环酸在全膝关节置换术中的应用评价

目的评价氨甲环酸在全膝关节置换术中减少出血的疗效。方法101例患者随机分为氨甲环酸组(n = 51)和安慰剂组(n = 50)。比较患者的以下参数:血红蛋白降低、估计总失血量、排液量和术后输血率。结果两组比较，差异有统计学意义(p <0.05)以下参数:血红蛋白降低，红细胞压积降低，估计失血量和排血量。氨甲环酸组各项指标均较低。只有安慰剂组患者需要输血。结论静脉注射氨甲环酸可有效减少全膝关节置换术患者出血。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista Brasileira de Ortopedia (English Edition)

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