Effects of solmach on alcohol hangover model in mice.

Abstract

Alcohol hangover is an unpleasant state caused by acetaldehyde, which is produced by partial oxidation of ethanol. Treating hangover is important from the viewpoint of preventing excessive drinking. In the present study, we attempted to produce mouse model of alcohol hangover by intraperitoneal pretreatment with cyanamide at 12.5 mg/kg followed by oral ethanol at 1.6 g/kg. The mice showed decrease of spontaneous locomotor activity and food intake. Thus, it is suggested that the hangover model was successively established by co-administration of cyanamide and ethanol. Solmack, a product based on herbal medicine for stomach anda pproved as medical drug, recovered decrease of spontaneous locomotor activity and tended to recover decrease of food intake in the.hangover model mice. Other refreshing drinks did not show such effects, though they contain herbal medicine ingredients to some extent. Our model in mice might be useful to detect effective treatment for alcohol hangover.