Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence最新文献

The Serigaya Methamphetamine Relapse Prevention Program (SMARPP) cognitive behavioral therapy was implemented among 38 substance. abusers in 12-Step Program Treatment Centers operated by:the Drug Addiction Rehabilitation Center (DARC). Tochigi DARC members (20 patients) started SMARPP after attending daily programs in the treatment centers for an extended time (mean period, 17.4 months). Chiba and Tateyama DARC members (18 patients) started SMARPP soon after initiation of treatment (mean period, 1.2 months). We provided SMARPP for approximately 70 days in the treatment centers, in addition to the regular programs, and examined changes in the participants before and after SMARPP. The results showed that the Tochigi DARC members improved significantly after 70 days based on scores from the "taking steps" subscale of the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES) (Wilcoxon rank sum test, p=0.041) and the "tension-anxiety" subscale of the Profile of Mood States (POMS) (Wilcoxon rank sum test, p=0.004). However, the Chiba and Tateyama DARC members did not improve. In the 12-Step Program Treatment Centers, cognitive behavioral therapy-such as SMARPP seems to be more effective if it is implemented later rather immediately after regular programs.

Chronic alcohol consumption can cause dysbiosis, but it is difficult to determine the effect of alcohol on the structure and activity of gastrointestinal tract microbiota. We therefore designed a noninvasive hydrogen breath test (HBT) to investigate the alteration in the chemical profile of gut microbiota in ethanol-fed rats. Thirteen F344/DuCri rats were fed on a commercial mash food with 16% ethanol solution drinking fluid from 4 weeks of age. HBTs were carried out on six 8-week-old and seven 24-week-old ethanol-fed rats. As controls, HBTs were carried out on sixteen 8-week-old, six 24-week-old, and five 48-week-old male rats. Six 24-week- old male rats were examined twice at 1-week intervals. HBTs were performed after fasting for 24 hr. Rats were orally administrated 4 mL/kg of 65% lactulose solution and housed in an animal chamber. The expired air was collected in a breath-sampling bag at 10-min intervals for 180 min. The hydrogen (H2) and methane (CH4) levels in the breath sample were measured using a breath analyzer and were expressed.as parts- per million (ppm). Elevated H2 and CH4 levels were more frequent in male rats. Maximal values of H2 and CH4 were highest in 8-week- old rats, followed by 48-week-old and 24-week-old rats. No ethanol-fed rat exhaled more than 2 ppm of H2 or CH4 until 180 min after the oral administration of lactulose, unlike the controls. This alteration was more obvious than that of aging or gender differentiation. We conclude that there is a close association between chronic ethanol consumption and H2 and CH4 production. An asymptomatic heavy drinker might have dysbiosis that involves gut microbiota with lower fermentation performance.

e-Health is the use of information and communication technologies for health, such as in patient-treatment programs, education for health care professionals, and monitoring public health. Web-/Internet-based programs, mobile applications, and wearable devices have been developed and adapted to various diseases and are now increasingly used to promote individual self-care of health. In the field of addiction, there has been a gap between potential treatment needs and available treatment services, and as such, it is necessary to develop new treatments that- are flexible and accessible. The authors developed a web-based relapse prevention program prototype dalled -"e-SMARPP" for drug users in Japan and assessed usability. Qualitative comments from pilot study participants were assessed in detail.-The authors found areas for improvement based on participant comments and revised e-SMARPP. The main areas identified for improvement included: 1) simplify video content regarding prelease prevention sessions, 2) refine the self-monitoring calendar to monitor various health-related conditions, and 3) revise glitches that occurred when used with a smartphone. In developing an e-health program, it is important to consider commeits from targeted users to make the program user-friendly and effective.

This study focused on patients receiving specialized outpatient (n=26) care to improve addiction behavior (mainly patients with alcohol dependency) and investigated their preferences for terms that describe the relationship between a patient and the object of his or her addiction and how those preferences correlated with the patient's current stage of recovery. The results showed a correlation between a preference for the term "dependence" and a stagnated recovery and a correlation between a preference for the term "overindulgence" and recovery progress (p<0.05). This was a correlation study, so it did not reveal the existence of a causal relationship. It did, however, suggest that terms implying self-directedness, such as "overindulgence" or "addiction," are preferable to the term "dependence" when providing treatment, because they allow.the patient to have a more autonomous self-image. However, the words "use disorder" and "habit" are safe in the sense that they are neutral, so these words are useful when beginning treatment, etc., in a patient-centered care setting, such as one that utilizes Shared Decision Making (SDM).

It-is well known that dopamine is necessary for motor function, reward-motivated behaviors. The principal target of dopamine is medium spiny neurons (MSNs), which are a special type of GABAergic inhibitory cell that represents,90% of the neurons within the striatum, including the nucleus accumbens (NAc). There is a distinct class of spatially intermixed MSNs that express dopamine type 1 or 2 receptors (DlR-MSNs or D2R-MSNs, respectively). The D1R-MSN and D2R-MSN pathways control the dynamic balance in the basal ganglia circuit. D1R is coupled -to adenylate cyclase through Golf to activate protein kinase A (PKA), whereas D2R inhibits adenylate cyclase through Gi. Although PKA has been implicated in reward signals downstream of D1Rs by pharmacological approaches, there is no direct evidence indicating that PKA in DlR-MSNs regulates neuronal excitability and reward-related behaviors. We have established the system in which enzymatic activity can be manipulated in the NAc under the control of specific promoters for DlR-MSNs using adeno-associated virus (AAV)-mediated conditional'transgenic techniques. We have also found novel PKA substrates in dopamine receptor signaling using phosphoproteomic approach. This review article focuses on the PKA and its substrates to understand dopamine-related signals in the MSNs. We discuss phosphoproteomic approaches for' comprehensively screening of dopamine signaling. Finally, we highlight RapI pathway as a novel reward signal in vivo.

Purpose: . In the last-decade, the treatment of drug offenders in Japanese prisons has changed from severe punishment to a therapeutic approach. This study aimed to review studies that evaluated the effectiveness of relapse prevention guidance for drug- dependent inmates in Japan.

Methods: We searched three databases: Ichushi; the Japanese correctional library database; and- PubMed. The inclusion criteria were: 1) the guidance was conducted in prisons in Japan; 2) the participants were Japanese adult inmates; 3) the evaluations were reported in quanti- tative investigations and original articles in Ichushi and PubMed; and, 4) the evaluations were reported in quantitative investigations in the Japanese correctional library database.

Results: In total, we identified 13 studies. Three studies.used comparison groups, and two studies included follow-up after the inmates' : release. Two studies-used recidivism and one used treatment persistence as behavioral outcomes. Almost all of the studies used psychological scales. Self-efficacy measures were the most commonly used, and the second most common scale was the Stage of Change Readiness and Treatment Eagerness Scale (SOCRATES).

Conclusion: Our findings indicate that SOCRATES is the most useful psychological outcome scale in assessing the effectiveness of. relapse prevention guidance for drug offenders in Japan. However, evidence is lacking, as most studies were before-and-after studies that only assessed psychological outcomes. More follow-up studies after release that include comparison groups and investigate behavioral outcomes are needed.

In this review, current progress of neurobehavioral research using animal model of dependence and/or addiction is described in light of DSM-5. Although the terms "dependence" and "abuse" are deleted in DSM-5, the concept of dependence and the related animal experiments, drug self-administration, conditioned place preference, and drug discrimination are still useful to predict abuse liability of chemical substances. At the same time, it is necessary to model addictive nature of behavior in animals. Impulsivity, compulsivity, and comorbidity of addiction to other mental disorders are the major topics of such research area. At the same time, basic research aimed at treatment of dependence/addiction has been progressed. For example, a methamphetamine monoclonal antibody, a new chemical acting on DARPP-32 (dopamine and c-AMP-regulated phophoprotein-32), a galanin analogue, oxytocin, and others are included in such attempt. As DSM-5 mentioned the brain reward system as the major site of substance-related and addictive disorders, clinicians would be more interested in biological substrates of dependence/addiction. It is expected that the emergence of new diagnostic criteria promotes mutual communication between basic and clinical researchers.

Forensic pathologists.frequently encounter sudden natural.death of alcoholic in which fatty liver is the only pathological finding detected at autopsy, however, characteristics of postmortem CT (PMCT) of sudden death of alcoholic have not been reported so far. In this study, we investigated radiographic measurements of PMCT of the cases diagnosed as sudden death of alcoholic (ALC), and compared them with those of other causes of death (IHD; ischemic heart disease, SV; starvation), with reference to autopsy findings. The cardio-thoracic ratio, the cross-sectional area of the inferior vena cava and the radio density of the lungs of ALC on PMCT were significantly lower than those of IHD, and tended to be midway between IHD and SV. These findings were in parallel with the total heart blood volume at autopsy and the extent of lung edema on histopathological findings. In addition, the radiodensity of the liver of ALC was significantly lower than the other groups, which was in parallel with the extent of fatty deposit in the hepatocytes on histopathology. More than 60% of ALC cases showed BMI < 18.0, and acetone was detected in blood in 87.5% of ALC cases. The lower radiodensity of the liver, and lack of signs suggestive of significant pulmonary edema and congestion in the great vessels, on PMCT, are considered to mirror terminal pathophysiology of sudden death of alcoholic, such as severe fatty liver- disease and metabolic disturbance (e.g., concomitant volume depletion with alcoholic ketoacidosis). Utilization of these findings on PMCT may serve to discern sudden death of alcoholic from other causes of death, in combination with detailed scene investigation, pathological, toxicological and biochemical analysis.

A large body of literature indicates that neural adaptations induced by cocaine in the mesocorticolibic system cause addictive behaviors. Emerging evidence suggests that the laterdorsal tegmental nucleus (LDT), which contains cholinergic, glutamatergic and GABAergic neurons and innervates the ventral tegmental area (VTA), might also contribute to the development of cocaine addiction. In this review, we summarize our recent findings showing that neuroplasticity elicited by cocaine administration in LDT cholinergic neurons is involved in the expression of addictive behaviors. Ex vivo electrophysiological recordings obtained from repeatedly cocaine administered rats revealed and increased excitatory synaptic transmission to and enhanced intrinsic membrane excitability in LDT cholinergic neurons. The former depended on enhanced glutamate release probability form presynaptic terminals and the latter was mediated by increased persistent sodium conductance. Additionally, intra-LDT administration of AMPA/HMDA receptor antagonists or a persistent sodium channel blocker attenuated the expression of cocaine-induced conditioned place preference. These findings suggest that chronic cocaine exposure-induced neuroplasticity in LDT cholinergic neurons may activate LDT cholinergic neurons, which in turn may enhance the activity of dopamine neurons in the VTA, leading to the development of cocaine addiction.

It is important to screen for alcohol consumption and drinking customs by using a stan- dardized method. The aim of this study was to investigate whether standardized questionnaire was useful for predicting alcohol consumption. A cross-sectional study using the Alcohol Use Disorders Identification Test (AUDIT) was conducted in 334 outpatients who consulted the Internal Medicine Department of Osaka City Juso Hospital. The patients completed self-reported questionnaires and underwent a diagnostic interview, physical examination, and laboratory testing. Forty (23%) male patients reported daily alcohol consumption 40 g, and 16 (10%) female patients reported consumption 20 g. The optimal cutoff values of hazardous drinking (all patients)/ drinker (male)/ drinker (female) were calculated using a 10-fold cross validation, resulting in an optimal AUDIT score cutoff of 8.2/ 7.2/ 6.1, with sensitivity of 95.5%/ 96.3%/ 88.9%, specificity of 87.0%/ 96.3%/ 88.9%, false positive rate of 13.0%/ 9.4%/6.6%, false negative rate of 4.5%/ 3.'%/ 11.1%, and area under the receiver operating characteristic curve of 0.97/ 0.98/ 0.99. In conclusion, this study showed that the AUDIT score was useful for predicting alcohol consumption.