Exploration of Adhesion Molecule Expression in Cardiac Muscle of Early Atherosclerosis Dyslipidemic Sprague Dawley Rats.

Q2 Pharmacology, Toxicology and Pharmaceutics Open Medicinal Chemistry Journal Pub Date : 2018-10-24 eCollection Date: 2018-01-01 DOI:10.2174/1874104501812010124

Titin A Wihastuti, Fitria N Aini, Nurul C Lutfiana, Teuku Heriansyah, Nafisatuz Zamrudah

{"title":"Exploration of Adhesion Molecule Expression in Cardiac Muscle of Early Atherosclerosis Dyslipidemic Sprague Dawley Rats.","authors":"Titin A Wihastuti, Fitria N Aini, Nurul C Lutfiana, Teuku Heriansyah, Nafisatuz Zamrudah","doi":"10.2174/1874104501812010124","DOIUrl":null,"url":null,"abstract":"Objective: This study is aimed to examine the expression of ICAM-1 and VCAM-1 in cardiac tissue of dyslipidemic Sprague Dawley rats.Methods: Eight Sprague Dawley strain rats, with 150-200 gram body weight, were divided into two groups. The control group was fed a standard diet, the positive control group was fed a high-fat diet as our previous study for 8 weeks. The pattern of distribution of ICAM-1 and VCAM-1 in cardiac muscle cell was examined by immunofluorescence and observed with a confocal laser scanning microscope. Lipid profile was also examined at the end of the study.Result: Independent t-test showed no differences in ICAM-1 and VCAM-1 expression in cardiac muscle of hypercholesterol-diet-fed Sprague Dawley rat compared to control.Conclusion: The expression of ICAM-1 and VCAM-1 in cardiac muscle did not change after the onset of atherosclerosis.","PeriodicalId":39133,"journal":{"name":"Open Medicinal Chemistry Journal","volume":"12 ","pages":"124-129"},"PeriodicalIF":0.0000,"publicationDate":"2018-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210500/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Medicinal Chemistry Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874104501812010124","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: This study is aimed to examine the expression of ICAM-1 and VCAM-1 in cardiac tissue of dyslipidemic Sprague Dawley rats.

Methods: Eight Sprague Dawley strain rats, with 150-200 gram body weight, were divided into two groups. The control group was fed a standard diet, the positive control group was fed a high-fat diet as our previous study for 8 weeks. The pattern of distribution of ICAM-1 and VCAM-1 in cardiac muscle cell was examined by immunofluorescence and observed with a confocal laser scanning microscope. Lipid profile was also examined at the end of the study.

Result: Independent t-test showed no differences in ICAM-1 and VCAM-1 expression in cardiac muscle of hypercholesterol-diet-fed Sprague Dawley rat compared to control.

Conclusion: The expression of ICAM-1 and VCAM-1 in cardiac muscle did not change after the onset of atherosclerosis.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

早期动脉粥样硬化血脂异常 Sprague Dawley 大鼠心肌中粘附分子表达的探索

研究目的本研究旨在检测血脂异常的 Sprague Dawley 大鼠心脏组织中 ICAM-1 和 VCAM-1 的表达：方法：将 8 只体重为 150-200 克的 Sprague Dawley 株大鼠分为两组。对照组饲喂标准饮食，阳性对照组饲喂高脂饮食（与我们之前的研究相同），为期 8 周。用免疫荧光法检测心肌细胞中 ICAM-1 和 VCAM-1 的分布模式，并用激光共聚焦扫描显微镜进行观察。研究结束时还检测了血脂谱：结果：独立t检验显示，与对照组相比，高胆固醇饮食喂养的Sprague Dawley大鼠心肌中ICAM-1和VCAM-1的表达没有差异：结论：动脉粥样硬化发生后，ICAM-1和VCAM-1在心肌中的表达没有变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Open Medicinal Chemistry Journal Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.40

自引率

0.00%

发文量