It's Getting Hot in Here: Targeting Cancer Stem-like Cells with Hyperthermia.

Journal of stem cell and transplantation biology Pub Date : 2017-01-01 Epub Date: 2017-12-29
Haidong Huang, Kevin Yu, Alireza Mohammadi, Efstathios Karanthanasis, Andrew Godley, Jennifer S Yu
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Abstract

Cancer stem-like cells (CSCs) are a subset of cancer cells that are resistant to conventional radiotherapy and chemotherapy. As such, CSCs have been recognized as playing a large role in tumor initiation and recurrence. Although hyperthermia is broadly used in cancer treatment either alone or in combination with radio- or chemo-therapy, its potential to target CSCs is not well understood. In this review, we discuss different types of hyperthermia and potential mechanisms of action in cancer treatment, particularly in regards to killing CSCs.

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这里越来越热:用高温疗法靶向癌症干细胞。
癌症干细胞样细胞(Cancer stem-样cells, CSCs)是对常规放疗和化疗具有耐药性的癌细胞的一个子集。因此,CSCs已被认为在肿瘤的发生和复发中起着重要作用。尽管热疗在癌症治疗中被广泛使用,无论是单独使用还是与放疗或化疗联合使用,但其靶向CSCs的潜力尚不清楚。在这篇综述中,我们讨论了不同类型的热疗及其在癌症治疗中的潜在作用机制,特别是在杀死csc方面。
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