Topical hyaluronic acid in the management of oral lichen planus: A comparative study

Q1 Medicine Journal of Investigative and Clinical Dentistry Pub Date : 2018-12-17 DOI:10.1111/jicd.12385

Ahmed S. Hashem, Rakhi Issrani, Tamer E. E. Elsayed, Namdeo Prabhu

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引用次数: 15

Abstract

Aim

Oral lichen planus (OLP) is a chronic mucocutaneous disorder seen in clinical dental practice. Despite the progress in research and advances in knowledge, the successful management of OLP is still difficult to achieve. The aim of the present study was to compare the therapeutic effects of triamcinolone (TA) preparation (0.1%) with hyaluronic acid (HA) preparation (0.2%) in the management of OLP.

Methods

In total, 40 patients of any age or sex who had symptomatic OLP were selected and randomly divided into two groups. Group I received topical 0.1% TA, and group II received topical 0.2% HA preparation three times per day for a period of 4 weeks. Basement data were recorded for each patient. Patients were evaluated on days 14 and 21, and after completing the course of treatment. The visual analog scale (VAS) was used for evaluating pain and burning sensation, along with an evaluation of the degree of erythema and mean area of the lesion. Data were analyzed by SPSS 17.0 software using Mann-Whitney and t test. P ≤ 0.05 was considered statistically significant.

Results

Our results showed considerable improvement in all of the parameters evaluated. Baseline characteristics, including pain score, size, and clinical characteristics of the lesions, were not different between the two treatment groups. Both TA and HA were found to reduce the VAS score, the degree of erythema, and size of the lesions after treatment.

Conclusion

The application of HA is suggested, and is an effective substitute for TA in the treatment of OLP.

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局部透明质酸治疗口腔扁平苔藓的比较研究

目的口腔扁平苔藓(OLP)是临床上常见的一种慢性口腔黏膜疾病。尽管研究进展和知识进步，但成功的OLP管理仍然难以实现。本研究的目的是比较曲安奈德(0.1%)制剂与透明质酸(0.2%)制剂治疗OLP的疗效。方法选择有症状性OLP的患者40例，年龄不限，性别不限，随机分为两组。组1接受0.1% TA外用，组2接受0.2% HA制剂外用，每天3次，连续4周。记录每位患者的基础资料。在第14天和第21天以及完成疗程后对患者进行评估。采用视觉模拟评分(VAS)评估疼痛和烧灼感，同时评估红斑程度和平均病变面积。数据分析采用SPSS 17.0软件，采用Mann-Whitney检验和t检验。P≤0.05认为有统计学意义。结果我们的结果显示，所有评估的参数都有相当大的改善。基线特征，包括疼痛评分、大小和病变的临床特征，在两个治疗组之间没有差异。治疗后发现TA和HA均可降低VAS评分、红斑程度和病变大小。结论羟基磷灰石是治疗OLP的有效替代药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Investigative and Clinical Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： Journal of Investigative and Clinical Dentistry (JICD) aims to publish quality, peer reviewed original research and topical reviews on all aspects of investigative and clinical dentistry and craniofacial research, including molecular studies related to oral health and disease. Although international in outlook, the Editor especially encourages papers from the Asia Pacific. The journal also aims to provide clinicians, scientists and students of dentistry with a knowledge transfer platform for rapid publication of reports through an international journal, which will be available free online until 2012. Its scope, therefore, is broad, inclusive and international, but with a particular focus on Asia Pacific. The Editor welcomes manuscripts in the following key thematic areas in oral and maxillofacial sciences: Community Dentistry and Oral Epidemiology, Conservative Dentistry, Dental Biomaterials, Dental Pedagogy, Endodontics and Traumatology, Implant Dentistry, Oral Biosciences, Oral and Maxillofacial Surgery, Oral Medicine, Oral Pathology and Oral Microbiology, Orthodontics, Oral Radiology, Oral Rehabilitation, Paedodontics, Periodontology and Periodontal Medicine.

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