A perspective on partially hydrolyzed protein infant formula in nonexclusively breastfed infants.

Korean Journal of Pediatrics Pub Date : 2019-05-01 Epub Date: 2019-01-14 DOI:10.3345/kjp.2018.07276
Yvan Vandenplas, Zakiudin Munasir, Badriul Hegar, Dewi Kumarawati, Ahmad Suryawan, Muzal Kadim, Julistio Tb Djais, Ray Wagiu Basrowi, Deni Krisnamurti
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引用次数: 19

Abstract

The World Health Organization recommends that infants should be exclusively breastfed for the first 6 months of life to provide optimal nutrition in this critical period of life. After this, infants should receive nutritionally adequate and safe complementary foods while breastfeeding continues for up to 2 years of age or beyond. For nonbreastfed infants, infant formula is an available option to provide the nutrition needed. Infant formula is usually prepared from industrially modified cow's milk and processed to adjust for the nutritional needs of infants. However, cow's milk is one of the most common causes of food allergy, affecting 2%-5% of all formula-fed infants during their first year of life. One strategy to prevent cow's milk allergy in nonbreastfed infants is the use of partially hydrolyzed formula (pHF) in high-risk infants, which are infants born in families with atopic disease. However, based on an epidemiological study, approximately half of the infants who develop allergy are not part of the at-risk group. This is because the non-at-risk group is significantly larger than the at-risk group and the non-at-risk infants have approximately 15% risk of developing allergies. This study aimed to evaluate the effects of partially hydrolyzed whey formula (pHF-W) in nonbreastfed infants and determine whether pHF-W can prevent atopic disease in high-risk infants and can be used as routine starter formula regardless of the allergy risk status.

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部分水解蛋白婴儿配方奶粉对非纯母乳喂养婴儿的影响。
世界卫生组织建议,婴儿应在出生后的头6个月完全母乳喂养,以便在这一关键时期提供最佳营养。在此之后,婴儿应接受营养充足和安全的补充食品,同时继续母乳喂养至2岁或以上。对于非母乳喂养的婴儿,婴儿配方奶粉是提供所需营养的一种可用选择。婴儿配方奶粉通常由工业改良的牛奶制成,并经过加工以适应婴儿的营养需求。然而,牛奶是食物过敏最常见的原因之一,在所有配方奶喂养的婴儿中,有2%-5%在出生后的第一年受到影响。预防非母乳喂养婴儿对牛奶过敏的一种策略是在高风险婴儿中使用部分水解配方奶粉(pHF),这些婴儿出生在患有特应性疾病的家庭。然而,根据一项流行病学研究,大约一半发生过敏的婴儿并不属于高危人群。这是因为无过敏风险的婴儿明显多于有过敏风险的婴儿,无过敏风险的婴儿有大约15%的过敏风险。本研究旨在评估部分水解乳清配方奶粉(pHF-W)在非母乳喂养婴儿中的作用,并确定pHF-W是否可以预防高危婴儿的特应性疾病,是否可以作为常规的起始配方奶粉,而不考虑过敏风险状态。
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期刊介绍: Korean J Pediatr covers clinical and research works relevant to all aspects of child healthcare. The journal aims to serve pediatricians through the prompt publication of significant advances in any field of pediatrics and to rapidly disseminate recently updated knowledge to the public. Additionally, it will initiate dynamic, international, academic discussions concerning the major topics related to pediatrics. Manuscripts are categorized as review articles, original articles, and case reports. Areas of specific interest include: Growth and development, Neonatology, Pediatric neurology, Pediatric nephrology, Pediatric endocrinology, Pediatric cardiology, Pediatric allergy, Pediatric pulmonology, Pediatric infectious diseases, Pediatric immunology, Pediatric hemato-oncology, Pediatric gastroenterology, Nutrition, Human genetics, Metabolic diseases, Adolescence medicine, General pediatrics.
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