HER2 overexpression and correlation with other significant clinicopathologic parameters in Ivorian breast cancer women.

Q2 Medicine BMC Clinical Pathology Pub Date : 2019-01-17 eCollection Date: 2019-01-01 DOI:10.1186/s12907-018-0081-4

Nguiessan Alphonse Aman, Brahima Doukoure, Kouadio Donatien Koffi, Baumaney Sylvanus Koui, Zie Cheick Traore, Mohamed Kouyate, Ahoua Benjamin Effi

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引用次数: 23

Abstract

Background: The overexpression of HER2 is associated with worse prognosis of breast cancer which responds favourably to anti-HER2 therapy. The objective of this study was to determine the frequency of HER2 and its association with clinicopathologic factors in breast cancer in Ivory Coast.

Methods: The study included 608 patients who were histologically diagnosed with invasive primary breast carcinoma. The immunohistochemistry testing for ER, PR, and HER2 was performed on the formalin fixed paraffin-embedded blocks of breast tissue of these patients. The analysis of variance and the Chi-Square Test were used to examine the association of the HER2 status with clinicopathologic prognostic features.

Results: The average age of patients was 47 ± 11 years. Among 608 patients, 355 (58.4%) were premenopausal. Invasive ductal carcinoma of no specific type (511 cases, 84.1%) was the most frequent histologic type. Grade II tumors were 59.8%. The positivity of ER, PR, and ER/PR was 334 cases (54.9%), 252 cases (41.4%), and 356 cases (58.5%), respectively. HER2 was overexpressed in 105 cases (17.3%). The overexpression of HER2 was significantly correlated with Nottingham grade (p = 0.007). No association was observed between HER2 expression and age (p = 0.568), menopausal status (p = 0.929), histologic type (p = 0.666), ER (p = 0.137), PR (p = 0.396), and ER/PR (p = 0.134).

Conclusion: Breast cancer occurs in young women. HER2 status is closely related to Nottingham grade. The immunohistochemical analysis of HER2 has prognostic and therapeutic implications, and thus, contributing to efficient clinical management of patients.

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科特迪瓦乳腺癌妇女中HER2过表达及其与其他重要临床病理参数的相关性

背景:HER2过表达与乳腺癌预后不良相关，而抗HER2治疗对乳腺癌预后有利。本研究的目的是确定科特迪瓦乳腺癌中HER2的频率及其与临床病理因素的关系。方法:本研究纳入608例经组织学诊断为浸润性原发性乳腺癌的患者。采用福尔马林固定石蜡包埋乳腺组织块进行ER、PR、HER2免疫组化检测。采用方差分析和卡方检验检验HER2状态与临床病理预后特征的关系。结果:患者平均年龄47±11岁。608例患者中，355例(58.4%)为绝经前患者。无特异性浸润性导管癌(511例，84.1%)是最常见的组织学类型。II级肿瘤占59.8%。ER阳性334例(54.9%)，PR阳性252例(41.4%)，ER/PR阳性356例(58.5%)。HER2过表达105例(17.3%)。HER2过表达与诺丁汉分级显著相关(p = 0.007)。HER2表达与年龄(p = 0.568)、绝经状态(p = 0.929)、组织学类型(p = 0.666)、ER (p = 0.137)、PR (p = 0.396)、ER/PR (p = 0.134)无相关性。结论:乳腺癌多发于年轻女性。HER2状态与诺丁汉等级密切相关。HER2的免疫组织化学分析具有预后和治疗意义，因此有助于患者的有效临床管理。

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来源期刊

BMC Clinical Pathology Medicine-Pathology and Forensic Medicine

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： BMC Clinical Pathology is an open access journal publishing original peer-reviewed research articles in all aspects of histopathology, haematology, clinical biochemistry, and medical microbiology (including virology, parasitology, and infection control). BMC Clinical Pathology (ISSN 1472-6890) is indexed/tracked/covered by PubMed, CAS, EMBASE, Scopus and Google Scholar.