Anti-inflammatory potential of a carvedilol gel in the pulpal tissue of rats after dental bleaching: A histopathological evaluation

Q1 Medicine Journal of Investigative and Clinical Dentistry Pub Date : 2019-01-28 DOI:10.1111/jicd.12401

Lidiane M. Louzada, André L. F. Briso, Francine Benetti, Letícia B. Vieira, Rogério de Castilho Jacinto, Elói Dezan-Júnior, Luciano T. A. Cintra

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引用次数: 7

Abstract

Aim

Carvedilol is an antioxidant that decreases inflammation in periodontitis. The hydrogen peroxide (H₂O₂) of bleaching gel causes inflammation and necrosis of the dental pulp. In the present study, we evaluated the anti-inflammatory potential of carvedilol in the pulp of rats after bleaching.

Methods

The right upper molars of rats received 35% H₂O₂ (1× 30 minutes), and the left upper molars were used as the control. Half of the rats received carvedilol gel (1× 10 minutes), forming the following groups: bleached, bleached followed by carvedilol (bleached+carvedilol), and control. After 2 and 30 days (N = 7 hemi-maxillae/group), the rats were killed for histological evaluation, and statistical tests were performed (P < 0.05).

Results

After 2 days, the bleached group showed necrosis in the occlusal third of the coronal pulp, and in the bleached+carvedilol group, severe inflammation (P > 0.05), both different from the control (P < 0.05). In the middle third, the bleached group showed severe inflammation, and the bleached+carvedilol group showed moderate inflammation (P > 0.05), with the only difference between the bleached and control groups (P < 0.05). In the cervical third, the bleached group showed moderate inflammation, and the bleached+carvedilol group showed mild inflammation (P > 0.05). The difference again was only between the bleached and control groups (P < 0.05). At 30 days, there was no inflammation and a marked amount of tertiary dentin in bleached teeth (P > 0.05).

Conclusion

Carvedilol gel has the potential of minimizing H₂O₂ damage, especially in deep regions of the dental pulp of rats after bleaching.

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卡维地洛凝胶在牙齿漂白后大鼠牙髓组织中的抗炎潜力:组织病理学评估

卡维地洛是一种抗氧化剂，可以减少牙周炎的炎症。漂白凝胶中的过氧化氢(H2O2)会引起牙髓发炎和坏死。在本研究中，我们评估了卡维地洛在大鼠牙髓漂白后的抗炎潜力。方法大鼠右上磨牙接受35% H2O2 (1× 30 min)治疗，左上磨牙作为对照组。一半大鼠给予卡维地洛凝胶(1× 10分钟)，分为漂白组、先漂白后卡维地洛组(漂白+卡维地洛)和对照组。分别于2、30 d (N = 7半颌/组)处死大鼠进行组织学评价，并进行统计学检验(P <0.05)。结果2 d后，漂白组冠状牙髓咬合三分之一处出现坏死，漂白+卡维地洛组出现严重炎症(P >0.05)，均与对照组不同(P <0.05)。在中间三分之一，漂白组出现严重炎症，漂白+卡维地洛组出现中度炎症(P >0.05)，漂白组与对照组之间仅有差异(P <0.05)。宫颈第三段，漂白剂组轻度炎症，漂白剂+卡维地洛组轻度炎症(P >0.05)。同样，这种差异只存在于漂白组和对照组之间(P <0.05)。第30天，漂白后的牙齿没有炎症，三级牙本质数量明显(P >0.05)。结论卡维地洛凝胶对大鼠牙髓漂白后深层H2O2损伤有一定的抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Investigative and Clinical Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

0.00%

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期刊介绍： Journal of Investigative and Clinical Dentistry (JICD) aims to publish quality, peer reviewed original research and topical reviews on all aspects of investigative and clinical dentistry and craniofacial research, including molecular studies related to oral health and disease. Although international in outlook, the Editor especially encourages papers from the Asia Pacific. The journal also aims to provide clinicians, scientists and students of dentistry with a knowledge transfer platform for rapid publication of reports through an international journal, which will be available free online until 2012. Its scope, therefore, is broad, inclusive and international, but with a particular focus on Asia Pacific. The Editor welcomes manuscripts in the following key thematic areas in oral and maxillofacial sciences: Community Dentistry and Oral Epidemiology, Conservative Dentistry, Dental Biomaterials, Dental Pedagogy, Endodontics and Traumatology, Implant Dentistry, Oral Biosciences, Oral and Maxillofacial Surgery, Oral Medicine, Oral Pathology and Oral Microbiology, Orthodontics, Oral Radiology, Oral Rehabilitation, Paedodontics, Periodontology and Periodontal Medicine.

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