Comparative Efficacy of Chitosan, Pectin Based Mesalamine Colon Targeted Drug Delivery Systems on TNBS-induced IBD Model Rats.

Q2 Medicine Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pub Date : 2020-01-01 DOI:10.2174/1871523018666190118112230

Amaldoss M J Newton, Prabakaran Lakshmanan

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引用次数: 4

Abstract

Objective: A number of natural polymer-based drug delivery systems targeting the colon are reported for different applications. Most of the research is based on the class of natural polymers such as polysaccharides. This study compares the anti-inflammatory effect of different polysaccharide based tablets on IBD when a drug carrier is targeted to the colon as matrix and coated systems.

Methods: The TNBS induced IBD Wistar rats were used as a model for the study. The microscopic and macroscopic parameters were studied in detail. Almost all the important IBD parameters were reported in this work.

Results: The results demonstrated that the polysaccharides are efficient in carrying the drugs to the colon. Reduction in the level of ulcer index (UI), Myeloperoxidase (MPO), and Malondialdehyde MDA, confirmed the inhibitory activity on the development of Reactive oxygen species (ROS). The increased level of Tumor necrosis factor (TNFα) an expression of colonic inducible nitric oxide synthase (iNOS) was lowered in treatments as compared to TNBS control.

Conclusion: The different polymer-based mesalamine (DPBM) confirmed the efficient anti- inflammatory activity on IBD induced rats. The increased level of glutathione (GSH), and superoxide dismutase (SOD) also confirmed the effective anti-inflammatory effect. A significant decrease in the ulcer score and ulcer area was reported. The investigation revealed that chitosan is superior to pectin in IBD treatment likewise polysaccharide-based matrix systems are superior to the coated system.

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壳聚糖、果胶为基础的美沙拉胺结肠靶向给药系统对tnbs诱导的IBD模型大鼠的疗效比较。

目的:一些天然聚合物为基础的药物输送系统针对结肠不同的应用报道。大多数研究都是基于天然聚合物，如多糖。本研究比较了当药物载体作为基质和包被系统靶向结肠时，不同多糖基片剂对IBD的抗炎作用。方法:以TNBS诱导IBD Wistar大鼠为模型进行研究。对其微观和宏观参数进行了详细的研究。本研究几乎报道了所有重要的IBD参数。结果:黄芪多糖具有较强的载药作用。溃疡指数(UI)、髓过氧化物酶(MPO)和丙二醛(MDA)水平的降低证实了其对活性氧(ROS)发育的抑制作用。肿瘤坏死因子(TNFα)和结肠诱导型一氧化氮合酶(iNOS)表达水平的升高与TNBS对照组相比有所降低。结论:不同聚合物基美色拉明(DPBM)对IBD诱导大鼠具有有效的抗炎活性。谷胱甘肽(GSH)和超氧化物歧化酶(SOD)水平的升高也证实了其有效的抗炎作用。据报道，溃疡评分和溃疡面积显著减少。研究表明，壳聚糖在IBD治疗中的效果优于果胶，多糖基基质体系优于包被体系。

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来源期刊

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-inflammatory & anti-allergy agents. Publishing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.