Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats.

IF 1 Q3 DENTISTRY, ORAL SURGERY & MEDICINE eJournal of Oral Maxillofacial Research Pub Date : 2018-12-30 eCollection Date: 2018-10-01 DOI:10.5037/jomr.2018.9404

Ricardo Basto Souza, Francisco Isaac Fernandes Gomes, Karuza Maria Alves Pereira, Paula Goes Pinheiro Dutra, Rodrigo Maranguape Silva da Cunha, Hellíada Vasconcelos Chaves, Mirna Marques Bezerra

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引用次数: 7

Abstract

Objectives: The purpose of this study was to determine the effects of strontium ranelate on ligature-induced periodontitis in rats and assess the putative involvement of heme oxygenase-1 (HO-1) pathway in these effects.

Material and methods: Male Wistar rats underwent nylon ligature placement around maxillary molars and were treated (v.o.) with strontium ranelate (20 or 100 mg/kg) for 7 days. After that, rats were euthanized and histomorphometric/histopathological analyses and RT-PCR for HO-1 expression were performed.

Results: Strontium ranelate (20 or 100 mg/kg) prevented bone resorption by 28% and 38%, respectively. Strontium ranelate treatment (100 mg/kg) up-regulated (P < 0.05) heme oxygenase-1 mRNA levels in the gingival tissues in comparison to control groups.

Conclusions: Strontium ranelate prevented periodontal bone loss in experimental periodontitis in rats while heme oxygenase-1 mRNA levels increased after treatment.

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雷奈酸锶提高大鼠血红素加氧酶-1的表达并减少牙槽骨丢失。

目的:本研究的目的是确定雷奈酸锶对大鼠结扎性牙周炎的作用，并评估血红素加氧酶-1 (HO-1)途径在这些作用中的可能参与。材料与方法:雄性Wistar大鼠上颌磨牙周围放置尼龙结扎，用雷奈酸锶(20或100 mg/kg)治疗7 d。然后对大鼠实施安乐死，进行组织形态学/组织病理学分析和HO-1表达的RT-PCR检测。结果:雷奈酸锶(20或100 mg/kg)对骨吸收的抑制作用分别为28%和38%。与对照组相比，雷奈酸锶处理(100 mg/kg)可上调牙龈组织血红素加氧酶-1 mRNA水平(P < 0.05)。结论:雷奈酸锶可预防实验性牙周炎大鼠牙周骨丢失，治疗后血红素加氧酶-1 mRNA水平升高。

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eJournal of Oral Maxillofacial Research

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12 weeks