Styliani Tziveleka, Maria Georgaki, E. Pettas, V. Savva, Erofili Papadopoulou, P. Katafygiotis, E. Vardas, Evangelia Piperi, N. Nikitakis
ABSTRACT Background Oral melanocytic nevi are relatively rare in comparison to their cutaneous counterparts. The aim of this manuscript is to present a case of acquired compound oral melanocytic nevi on the hard palatal mucosa of a child. Methods A 5-year-old female girl was referred for evaluation of a pigmented lesion on the hard palate. The lesion was asymptomatic and present for approximately 2 months. Oral clinical examination revealed a well-circumscribed brownish macule on the hard palatal mucosa, adjacent to the left first primary upper molar. Considering the recent onset of the lesion, biopsy was recommended, but the patient returned 3 years later, when increase in size with slight asymmetry and colour variation were noticed. An excisional biopsy was performed. Results Microscopic examination revealed nevus cells randomly distributed along the basal cell layer and organized into nests along the junctional area and within the papillary layer of lamina propria, while immunohistochemical evaluation showed positivity of nevus cells for SOX-10 and Melan-A. A final diagnosis of compound melanocytic nevi was rendered, and the patient was advised to attend regular follow-up appointments. Conclusions Although oral melanocytic nevi are rare in childhood, their potential development should not be overlooked. Acquired oral melanocytic nevi need to be differentiated from several other common (e.g. amalgam tattoo) and uncommon (e.g. melanoma) oral pigmented lesions, as well as from the more rare congenital oral melanocytic nevi. Oral melanocytic nevi with junctional activity (i.e. junctional, compound subtypes) appear to be more common in children, possibly reflecting an earlier developmental stage.
{"title":"Acquired Compound Melanocytic Nevus on the Palate of a Child: Report of a Case","authors":"Styliani Tziveleka, Maria Georgaki, E. Pettas, V. Savva, Erofili Papadopoulou, P. Katafygiotis, E. Vardas, Evangelia Piperi, N. Nikitakis","doi":"10.5037/jomr.2022.13105","DOIUrl":"https://doi.org/10.5037/jomr.2022.13105","url":null,"abstract":"ABSTRACT Background Oral melanocytic nevi are relatively rare in comparison to their cutaneous counterparts. The aim of this manuscript is to present a case of acquired compound oral melanocytic nevi on the hard palatal mucosa of a child. Methods A 5-year-old female girl was referred for evaluation of a pigmented lesion on the hard palate. The lesion was asymptomatic and present for approximately 2 months. Oral clinical examination revealed a well-circumscribed brownish macule on the hard palatal mucosa, adjacent to the left first primary upper molar. Considering the recent onset of the lesion, biopsy was recommended, but the patient returned 3 years later, when increase in size with slight asymmetry and colour variation were noticed. An excisional biopsy was performed. Results Microscopic examination revealed nevus cells randomly distributed along the basal cell layer and organized into nests along the junctional area and within the papillary layer of lamina propria, while immunohistochemical evaluation showed positivity of nevus cells for SOX-10 and Melan-A. A final diagnosis of compound melanocytic nevi was rendered, and the patient was advised to attend regular follow-up appointments. Conclusions Although oral melanocytic nevi are rare in childhood, their potential development should not be overlooked. Acquired oral melanocytic nevi need to be differentiated from several other common (e.g. amalgam tattoo) and uncommon (e.g. melanoma) oral pigmented lesions, as well as from the more rare congenital oral melanocytic nevi. Oral melanocytic nevi with junctional activity (i.e. junctional, compound subtypes) appear to be more common in children, possibly reflecting an earlier developmental stage.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123857385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Prodoehl, P. Thomas, J. Krzak, T. Hanke, Joseph Tojanic, James Thomas
ABSTRACT Objectives The effect of body posture on movement of the jaw and head has not yet been clearly established. The relationship between jaw and head movement has implications for conditions such as temporomandibular joint disorders which can be associated with neck pain. The purpose of this quasi-experimental study was to examine the effect of starting posture on three-dimensional movement of the jaw and head, and to examine the relationship between head and jaw movement during mouth opening. Material and Methods Fourteen healthy participants performed jaw opening to comfortable and maximal amounts from three starting body postures (neutral, slumped, upright) while three-dimensional movement of the head, jaw, and trunk was tracked. Separate repeated measures analyses of variance analyses examined the effect of posture on jaw and head rotation and translation, and Pearson product moment correlations examined the relationship between jaw opening and head rotation. Results Body posture significantly influenced maximal opening but not comfortable opening (P < 0.0033). There was a positive relationship between head extension and maximum opening in an upright posture (r = 0.74, P = 0.006), and head extension and comfortable opening in neutral and upright postures (r = 0.75 to 0.93, P < 0.0033), although there was no relationship between head extension and jaw opening in a slumped posture when opening comfortably. Conclusions Posture can affect three-dimensional movement of the jaw when opening. Negating the normal head extension that occurs with mouth opening when in a slumped posture has implications for the development of temporomandibular and neck problems in some individuals.
【摘要】目的身体姿势对下颌和头部运动的影响尚未明确。下颌和头部运动之间的关系对诸如可能与颈部疼痛相关的颞下颌关节紊乱等疾病有影响。本拟实验研究的目的是探讨起跳姿势对下颌和头部三维运动的影响，以及开口时头部和下颌运动的关系。材料与方法14名健康参与者在三种起始身体姿势(中性、倾斜、直立)下进行舒适的最大张开下巴，同时跟踪头部、下颌和躯干的三维运动。方差分析的单独重复测量分析检验了姿势对下颌和头的旋转和平移的影响，Pearson积差相关检验了下颌张开和头旋转之间的关系。结果体位对最大开口有显著影响，对舒适开口无显著影响(P < 0.0033)。直立体位的头伸与最大开口呈正相关(r = 0.74, P = 0.006)，中立体位和直立体位的头伸与舒适开口呈正相关(r = 0.75 ~ 0.93, P < 0.0033)，而俯卧体位的头伸与舒适开口无相关。结论开口时体位会影响下颌的三维运动。在一些人的颞下颌关节和颈部问题的发展中，在俯卧的姿势中，当嘴巴张开时，正常的头部伸展会被否定。
{"title":"Effect of Starting Posture on Three-Dimensional Jaw and Head Movement","authors":"J. Prodoehl, P. Thomas, J. Krzak, T. Hanke, Joseph Tojanic, James Thomas","doi":"10.5037/jomr.2022.13104","DOIUrl":"https://doi.org/10.5037/jomr.2022.13104","url":null,"abstract":"ABSTRACT Objectives The effect of body posture on movement of the jaw and head has not yet been clearly established. The relationship between jaw and head movement has implications for conditions such as temporomandibular joint disorders which can be associated with neck pain. The purpose of this quasi-experimental study was to examine the effect of starting posture on three-dimensional movement of the jaw and head, and to examine the relationship between head and jaw movement during mouth opening. Material and Methods Fourteen healthy participants performed jaw opening to comfortable and maximal amounts from three starting body postures (neutral, slumped, upright) while three-dimensional movement of the head, jaw, and trunk was tracked. Separate repeated measures analyses of variance analyses examined the effect of posture on jaw and head rotation and translation, and Pearson product moment correlations examined the relationship between jaw opening and head rotation. Results Body posture significantly influenced maximal opening but not comfortable opening (P < 0.0033). There was a positive relationship between head extension and maximum opening in an upright posture (r = 0.74, P = 0.006), and head extension and comfortable opening in neutral and upright postures (r = 0.75 to 0.93, P < 0.0033), although there was no relationship between head extension and jaw opening in a slumped posture when opening comfortably. Conclusions Posture can affect three-dimensional movement of the jaw when opening. Negating the normal head extension that occurs with mouth opening when in a slumped posture has implications for the development of temporomandibular and neck problems in some individuals.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130662484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Starch-Jensen, Julie Vitenson, Daniel Deluiz, Kimie Bols Østergaard, E. Tinoco
ABSTRACT Objectives The objective of the present systematic review was to evaluate the current knowledge of implant treatment outcome following lateral alveolar ridge augmentation with autogenous tooth block graft compared with autogenous bone block graft prior to implant placement. Material and Methods MEDLINE (PubMed), Embase and Cochrane Library search in combination with hand-search of relevant journals was conducted including human studies published in English through December 20, 2021. Comparative and non-comparative studies assessing lateral alveolar ridge augmentation with autogenous tooth block graft were included. Quality and risk-of-bias assessment were evaluated by Cochrane risk of bias tool, Newcastle-Ottawa Scale and GRADE system. Results One comparative study characterized by low grade and two non-comparative studies fulfilled the inclusion criteria. No significant difference in short-term implant survival, health status of the peri-implant tissue or frequency of complications between the two treatment modalities was observed. Postoperative dimensional changes of the alveolar ridge width were significant diminished with tooth block compared with bone block (P = 0.0029). Consequently, the gain in alveolar ridge width was significantly higher with tooth block, after 26 weeks (P = 0.014). However, a higher frequency of short-term peri-implant mucositis was observed with tooth block. Conclusions Lateral alveolar ridge augmentation with tooth block seems to be a suitable alternative to bone block. However, results of the present systematic review are based on short-term studies involving small patient samples. Further long-term randomized controlled trials are therefore needed before definite conclusions can be provided about the beneficial use of tooth block compared with bone block.
{"title":"Lateral Alveolar Ridge Augmentation with Autogenous Tooth Block Graft Compared with Autogenous Bone Block Graft: a Systematic Review","authors":"T. Starch-Jensen, Julie Vitenson, Daniel Deluiz, Kimie Bols Østergaard, E. Tinoco","doi":"10.5037/jomr.2022.13101","DOIUrl":"https://doi.org/10.5037/jomr.2022.13101","url":null,"abstract":"ABSTRACT Objectives The objective of the present systematic review was to evaluate the current knowledge of implant treatment outcome following lateral alveolar ridge augmentation with autogenous tooth block graft compared with autogenous bone block graft prior to implant placement. Material and Methods MEDLINE (PubMed), Embase and Cochrane Library search in combination with hand-search of relevant journals was conducted including human studies published in English through December 20, 2021. Comparative and non-comparative studies assessing lateral alveolar ridge augmentation with autogenous tooth block graft were included. Quality and risk-of-bias assessment were evaluated by Cochrane risk of bias tool, Newcastle-Ottawa Scale and GRADE system. Results One comparative study characterized by low grade and two non-comparative studies fulfilled the inclusion criteria. No significant difference in short-term implant survival, health status of the peri-implant tissue or frequency of complications between the two treatment modalities was observed. Postoperative dimensional changes of the alveolar ridge width were significant diminished with tooth block compared with bone block (P = 0.0029). Consequently, the gain in alveolar ridge width was significantly higher with tooth block, after 26 weeks (P = 0.014). However, a higher frequency of short-term peri-implant mucositis was observed with tooth block. Conclusions Lateral alveolar ridge augmentation with tooth block seems to be a suitable alternative to bone block. However, results of the present systematic review are based on short-term studies involving small patient samples. Further long-term randomized controlled trials are therefore needed before definite conclusions can be provided about the beneficial use of tooth block compared with bone block.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"213 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133627254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pooja Gangwani, Mohammed Almana, Basir A. Barmak, A. Kolokythas
ABSTRACT Objectives The purpose of this systematic review and meta-analysis is to examine the success rate of osseointegrated dental implants placed secondarily in fibula free flaps using the Albrektsson and colleagues criteria. Material and Methods A computerized database search was performed using PubMed, Embase, Web of Science and Cochrane CENTRAL. Specific ascertainment criteria were applied for the inclusion of the eligible studies. This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analysis PRISMA checklist. Risk of bias was assessed for all the included studies. Results The meta-analysis was carried using ten studies that met the inclusion criteria. The present review pooled data obtained from 242 patients (167 males and 75 females), with the age range of 13 to 79 years. A total of 848 dental implants were placed in the free fibula flaps. All dental implants were placed in a delayed fashion, ranging from 14 to 192 months. The estimated proportion of successful implants placed in fibula flaps used to reconstruct the maxillomandibular complex was 0.94 or 94% (95% CI [confidence interval] = 0.91 to 0.96]) with an insignificant heterogeneity of 37%, P = 0.12. Using a random effect model the annual implant failure rate was 0.02 with a 95% CI = 0.01 to 0.03. Conclusions The results of this systematic review and meta-analysis strongly indicate that using objective criteria, delayed implant placement in free fibula flaps is highly successful.
目的:本系统综述和荟萃分析的目的是使用Albrektsson和他的同事的标准来检查腓骨游离皮瓣二次放置骨整合牙种植体的成功率。材料与方法利用PubMed、Embase、Web of Science和Cochrane CENTRAL进行计算机数据库检索。采用特定的确定标准纳入符合条件的研究。本系统评价遵循系统评价和荟萃分析首选报告项目PRISMA清单。对所有纳入的研究进行偏倚风险评估。结果荟萃分析纳入了10项符合纳入标准的研究。本综述汇总了242例患者(167例男性，75例女性)的数据，年龄范围为13至79岁。游离腓骨皮瓣内共植入牙体848颗。所有种植牙均延迟放置，时间从14个月到192个月不等。用于重建上颌骨下颌骨复合体的腓骨皮瓣植入成功的比例估计为0.94或94% (95% CI[置信区间]= 0.91至0.96])，异质性为37%，P = 0.12。采用随机效应模型，种植体年失败率为0.02,95% CI = 0.01 ~ 0.03。结论本系统综述和荟萃分析的结果强烈表明，使用客观标准，游离腓骨瓣延迟植入是非常成功的。
{"title":"What Is the Success of Implants Placed in Fibula Flap? A Systematic Review and Meta-Analysis","authors":"Pooja Gangwani, Mohammed Almana, Basir A. Barmak, A. Kolokythas","doi":"10.5037/jomr.2022.13103","DOIUrl":"https://doi.org/10.5037/jomr.2022.13103","url":null,"abstract":"ABSTRACT Objectives The purpose of this systematic review and meta-analysis is to examine the success rate of osseointegrated dental implants placed secondarily in fibula free flaps using the Albrektsson and colleagues criteria. Material and Methods A computerized database search was performed using PubMed, Embase, Web of Science and Cochrane CENTRAL. Specific ascertainment criteria were applied for the inclusion of the eligible studies. This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analysis PRISMA checklist. Risk of bias was assessed for all the included studies. Results The meta-analysis was carried using ten studies that met the inclusion criteria. The present review pooled data obtained from 242 patients (167 males and 75 females), with the age range of 13 to 79 years. A total of 848 dental implants were placed in the free fibula flaps. All dental implants were placed in a delayed fashion, ranging from 14 to 192 months. The estimated proportion of successful implants placed in fibula flaps used to reconstruct the maxillomandibular complex was 0.94 or 94% (95% CI [confidence interval] = 0.91 to 0.96]) with an insignificant heterogeneity of 37%, P = 0.12. Using a random effect model the annual implant failure rate was 0.02 with a 95% CI = 0.01 to 0.03. Conclusions The results of this systematic review and meta-analysis strongly indicate that using objective criteria, delayed implant placement in free fibula flaps is highly successful.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128903317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Objectives This systematic review and meta-analysis study sought to review the efficacy of amoxicillin/metronidazole dose and duration time in the treatment of stage II - III grade C periodontitis (aggressive periodontitis) after current follow-up. Material and Methods An electronic search of the literature was performed in three main databases for relevant articles published until 31th of December 2021. According to the PRISMA statement, the extracted data from selected articles were pooled. The weighted mean difference (MD) and 95% confidence interval (CI) of clinical attachment level (CAL) gain and probing depth (PD) reduction at 3 and 6 months of follow-up were calculated. The heterogeneity of the data was evaluated by the I2 test. Results The results of six randomized clinical trials revealed significant improvement of clinical parameters in moderate and severe pockets. Prescription of 400 to 500 mg metronidazole caused significant CAL gain changes just in moderate pockets (MD = 1.82; 95% CI = 1.11 to 2.53; P < 0.05). Conclusions Amoxicillin/metronidazole has positive short-term effects as an adjunct to scaling and root planning for treatment of stage II - III grade C periodontitis. Higher doses of metronidazole (400 to 500 mg) are required for optimal efficacy regarding clinical attachment level gain.
{"title":"Amoxicillin/Metronidazole Dose Impact as an Adjunctive Therapy for Stage II - III Grade C Periodontitis (Aggressive Periodontitis) at 3- And 6-Month Follow-Ups: a Systematic Review and Meta-Analysis","authors":"M. Karrabi, Zahra Baghani","doi":"10.5037/jomr.2022.13102","DOIUrl":"https://doi.org/10.5037/jomr.2022.13102","url":null,"abstract":"ABSTRACT Objectives This systematic review and meta-analysis study sought to review the efficacy of amoxicillin/metronidazole dose and duration time in the treatment of stage II - III grade C periodontitis (aggressive periodontitis) after current follow-up. Material and Methods An electronic search of the literature was performed in three main databases for relevant articles published until 31th of December 2021. According to the PRISMA statement, the extracted data from selected articles were pooled. The weighted mean difference (MD) and 95% confidence interval (CI) of clinical attachment level (CAL) gain and probing depth (PD) reduction at 3 and 6 months of follow-up were calculated. The heterogeneity of the data was evaluated by the I2 test. Results The results of six randomized clinical trials revealed significant improvement of clinical parameters in moderate and severe pockets. Prescription of 400 to 500 mg metronidazole caused significant CAL gain changes just in moderate pockets (MD = 1.82; 95% CI = 1.11 to 2.53; P < 0.05). Conclusions Amoxicillin/metronidazole has positive short-term effects as an adjunct to scaling and root planning for treatment of stage II - III grade C periodontitis. Higher doses of metronidazole (400 to 500 mg) are required for optimal efficacy regarding clinical attachment level gain.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131431714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pooja Gangwani, Haley Harris, Molly Christie, Kyle Mecca, Basir A. Barmak, A. Kolokythas
ABSTRACT Objectives The aim of this retrospective comparative study was to evaluate the effects of implemented social and public health measures during the COVID-19 pandemic on the incidence and aetiology of maxillofacial injuries. Material and Methods A retrospective chart review of all the patients who had sustained maxillofacial injuries and presented to the emergency department of Strong Memorial Hospital between March 20th and June 24th, 2019 and 2020, were included in our study. The total study sample comprised of 335 patients (n = 140 in 2019 group, n = 195 in 2020 group). The primary outcome variables of the study were the number of cases and aetiology of maxillofacial injuries. Statistical analysis consisted of descriptive statistics, Chi-square, and two sample t-tests. Results The number of patients in the 2020 group was higher (n = 195) than the number of patients in the 2019 group (n = 140). Comparatively, there was an increase in the maxillofacial injuries during the stay-at-home period by (n = 55 [39.29%]). Although not statistically significant, the aetiology of injuries differed during the stay-at-home period compared to the normal times. Conclusions The number of maxillofacial injuries increased during the period of implemented social and public health measures during the early months of the COVID-19 pandemic. Such knowledge can provide valuable information for the establishment of prevention programs and effective health policies and help in the decision-making process pertaining to resource allocation in a dire situation of the pandemic.
{"title":"Aetiology and Epidemiology of Maxillofacial Injuries during the Stay-At-Home Period Due To the COVID-19 Pandemic: a Single Center Study","authors":"Pooja Gangwani, Haley Harris, Molly Christie, Kyle Mecca, Basir A. Barmak, A. Kolokythas","doi":"10.5037/jomr.2021.12404","DOIUrl":"https://doi.org/10.5037/jomr.2021.12404","url":null,"abstract":"ABSTRACT Objectives The aim of this retrospective comparative study was to evaluate the effects of implemented social and public health measures during the COVID-19 pandemic on the incidence and aetiology of maxillofacial injuries. Material and Methods A retrospective chart review of all the patients who had sustained maxillofacial injuries and presented to the emergency department of Strong Memorial Hospital between March 20th and June 24th, 2019 and 2020, were included in our study. The total study sample comprised of 335 patients (n = 140 in 2019 group, n = 195 in 2020 group). The primary outcome variables of the study were the number of cases and aetiology of maxillofacial injuries. Statistical analysis consisted of descriptive statistics, Chi-square, and two sample t-tests. Results The number of patients in the 2020 group was higher (n = 195) than the number of patients in the 2019 group (n = 140). Comparatively, there was an increase in the maxillofacial injuries during the stay-at-home period by (n = 55 [39.29%]). Although not statistically significant, the aetiology of injuries differed during the stay-at-home period compared to the normal times. Conclusions The number of maxillofacial injuries increased during the period of implemented social and public health measures during the early months of the COVID-19 pandemic. Such knowledge can provide valuable information for the establishment of prevention programs and effective health policies and help in the decision-making process pertaining to resource allocation in a dire situation of the pandemic.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130868738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Kassapidou, V. Stenport, C. Johansson, Anna-Karin Östberg, P. Johansson, L. Hjalmarsson
ABSTRACT Objectives To explore the in vitro cytokine expression of human peripheral blood mononuclear cells exposed to cobalt-chromium alloys, manufactured with different techniques, in comparison with commercially pure titanium grade 4 and titanium alloy grade 23. Material and Methods Peripheral blood mononuclear cells (PBMC) were collected from 10 healthy blood donors and exposed to machine-ground coin-shaped: (a) cobalt-chromium (Co-Cr) specimens (n = 5) manufactured by four techniques, i.e. cast, milled, laser melted and presintered milled; (b) commercially pure titanium grade 4; and (c) titanium alloy grade 23. The cells were cultured for 4, 24 and 72 hours followed by investigations of pro- and anti-inflammatory cytokine release using Bio-Plex Pro™. Results In general, the PBMC produced significantly more cytokines when exposed to the cast and presintered milled Co-Cr materials compared to laser melted, milled Co-Cr and titanium materials. Conclusions Within the limitation of the present study, it may be suggested that cast and presintered milled cobalt-chromium alloys provoke a stronger inflammatory response compared to milled and laser melted cobalt-chromium alloys and titanium materials.
{"title":"Inflammatory Response to Cobalt-Chromium Alloys Fabricated With Different Techniques","authors":"Maria Kassapidou, V. Stenport, C. Johansson, Anna-Karin Östberg, P. Johansson, L. Hjalmarsson","doi":"10.5037/jomr.2021.12403","DOIUrl":"https://doi.org/10.5037/jomr.2021.12403","url":null,"abstract":"ABSTRACT Objectives To explore the in vitro cytokine expression of human peripheral blood mononuclear cells exposed to cobalt-chromium alloys, manufactured with different techniques, in comparison with commercially pure titanium grade 4 and titanium alloy grade 23. Material and Methods Peripheral blood mononuclear cells (PBMC) were collected from 10 healthy blood donors and exposed to machine-ground coin-shaped: (a) cobalt-chromium (Co-Cr) specimens (n = 5) manufactured by four techniques, i.e. cast, milled, laser melted and presintered milled; (b) commercially pure titanium grade 4; and (c) titanium alloy grade 23. The cells were cultured for 4, 24 and 72 hours followed by investigations of pro- and anti-inflammatory cytokine release using Bio-Plex Pro™. Results In general, the PBMC produced significantly more cytokines when exposed to the cast and presintered milled Co-Cr materials compared to laser melted, milled Co-Cr and titanium materials. Conclusions Within the limitation of the present study, it may be suggested that cast and presintered milled cobalt-chromium alloys provoke a stronger inflammatory response compared to milled and laser melted cobalt-chromium alloys and titanium materials.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128058693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marie Kjærgaard Larsen, T. Kofod, T. Starch-Jensen
ABSTRACT Objectives Cryotherapy is frequently used to diminish postoperative sequelae following mandibular third molar surgery. The objective of this single-blinded randomized controlled trial was to assess the therapeutic efficiency of 30 minutes continuous cryotherapy on postoperative sequelae following surgical removal of mandibular third molars compared with no cryotherapy. Material and Methods Thirty patients (14 male and 16 female) including 60 mandibular third molars were randomly allocated to 30 minutes of immediately cryotherapy or no cryotherapy. Outcome measures included pain (visual analogue scale score), maximum mouth opening (trismus) and quality of life (oral health impact profile-14). Outcome measures were assessed preoperatively and one day, three days, seven days and one month following surgical removal of mandibular third molars. Descriptive and generalized estimating equation analyses were made. Level of significance was 0.05. Results No cryotherapy following surgical removal of mandibular third molars revealed a statistically significant lower visual analogue scale score of pain compared to thirty minutes of continuous cryotherapy after one day (P < 0.05). However, no statistically significant difference in trismus or oral health-related quality of life were revealed at any time point compared with no cryotherapy. Conclusions The therapeutic effect of 30 minutes continuous cryotherapy following surgical removal of mandibular third molars seem to be negligible. Thus, further randomized controlled trials assessing a prolonged application period of cryotherapy, alternative devices or use of intermittent cryotherapy are needed before definite conclusions and evidence-based clinical recommendations can be provided.
{"title":"The Use of Cryotherapy in Conjunction with Surgical Removal of Mandibular Third Molars: a Single-Blinded Randomized Controlled Trial","authors":"Marie Kjærgaard Larsen, T. Kofod, T. Starch-Jensen","doi":"10.5037/jomr.2021.12402","DOIUrl":"https://doi.org/10.5037/jomr.2021.12402","url":null,"abstract":"ABSTRACT Objectives Cryotherapy is frequently used to diminish postoperative sequelae following mandibular third molar surgery. The objective of this single-blinded randomized controlled trial was to assess the therapeutic efficiency of 30 minutes continuous cryotherapy on postoperative sequelae following surgical removal of mandibular third molars compared with no cryotherapy. Material and Methods Thirty patients (14 male and 16 female) including 60 mandibular third molars were randomly allocated to 30 minutes of immediately cryotherapy or no cryotherapy. Outcome measures included pain (visual analogue scale score), maximum mouth opening (trismus) and quality of life (oral health impact profile-14). Outcome measures were assessed preoperatively and one day, three days, seven days and one month following surgical removal of mandibular third molars. Descriptive and generalized estimating equation analyses were made. Level of significance was 0.05. Results No cryotherapy following surgical removal of mandibular third molars revealed a statistically significant lower visual analogue scale score of pain compared to thirty minutes of continuous cryotherapy after one day (P < 0.05). However, no statistically significant difference in trismus or oral health-related quality of life were revealed at any time point compared with no cryotherapy. Conclusions The therapeutic effect of 30 minutes continuous cryotherapy following surgical removal of mandibular third molars seem to be negligible. Thus, further randomized controlled trials assessing a prolonged application period of cryotherapy, alternative devices or use of intermittent cryotherapy are needed before definite conclusions and evidence-based clinical recommendations can be provided.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123528478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Papageorgiou, E. Pettas, Maria Georgaki, N. Nikitakis
ABSTRACT Background Several lesions of diverse origin may be detected in the oral cavity of children, affecting the oral mucosa, jaws, or teeth. In equivocal cases, their clinicopathologic features may show considerable overlap with various entities. We present a case of a “ring-like” hard mass around the cervical area of a primary tooth in a child and discuss the diagnostic challenges. Methods A 2.5 year-old girl was presented by her mother for evaluation of a painless left first primary lower incisor lesion, first noticed 5 months ago. Medical history was unremarkable, while previous injury or other incident could not be recalled by the patient’s mother. Clinical examination and a periapical radiograph were performed. Results The clinical examination revealed a yellowish, non-removable, hard in consistency, cylindrical mass, completely surrounding the cervical area of the left first primary lower incisor. A periapical radiograph was performed, revealing a cylindrical radiopacity of mild intensity encasing the tooth cervix and a diagnosis of a foreign body inserted around the tooth was made. Regular follow-up appointments were attended for the next 4 years in which mild but progressive gingival recession, revealing a larger part of the ring-like structure was observed. At age of 6, the tooth was extracted and a cylindrical structure was detached from the tooth, confirming its nature as a foreign body. Conclusions A foreign body surrounding the cervix of a tooth eventually becoming inseparable may cause a peculiar clinical and radiographic appearance and provoke diagnostic difficulties, especially in the lack of a relevant history.
{"title":"“Ring-Like Mass” Surrounding the Cervix of a Primary Incisor. Report of a Challenging Case","authors":"N. Papageorgiou, E. Pettas, Maria Georgaki, N. Nikitakis","doi":"10.5037/jomr.2021.12405","DOIUrl":"https://doi.org/10.5037/jomr.2021.12405","url":null,"abstract":"ABSTRACT Background Several lesions of diverse origin may be detected in the oral cavity of children, affecting the oral mucosa, jaws, or teeth. In equivocal cases, their clinicopathologic features may show considerable overlap with various entities. We present a case of a “ring-like” hard mass around the cervical area of a primary tooth in a child and discuss the diagnostic challenges. Methods A 2.5 year-old girl was presented by her mother for evaluation of a painless left first primary lower incisor lesion, first noticed 5 months ago. Medical history was unremarkable, while previous injury or other incident could not be recalled by the patient’s mother. Clinical examination and a periapical radiograph were performed. Results The clinical examination revealed a yellowish, non-removable, hard in consistency, cylindrical mass, completely surrounding the cervical area of the left first primary lower incisor. A periapical radiograph was performed, revealing a cylindrical radiopacity of mild intensity encasing the tooth cervix and a diagnosis of a foreign body inserted around the tooth was made. Regular follow-up appointments were attended for the next 4 years in which mild but progressive gingival recession, revealing a larger part of the ring-like structure was observed. At age of 6, the tooth was extracted and a cylindrical structure was detached from the tooth, confirming its nature as a foreign body. Conclusions A foreign body surrounding the cervix of a tooth eventually becoming inseparable may cause a peculiar clinical and radiographic appearance and provoke diagnostic difficulties, especially in the lack of a relevant history.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122026632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renata Scheeren Brum, K. Apaza-Bedoya, L. Labes, C. M. Volpato, A. Pimenta, C. Benfatti
ABSTRACT Objectives There is a concern whether the enhancement on implant surface roughness is responsible for higher biofilm formation, which acts as an aetiological factor for peri-implant diseases. The aim of the present systematic review was to answer the following question: “Are rough surfaces more susceptible to early biofilm formation when compared to smoother surfaces on titanium specimens?”. Material and Methods The research was performed on PubMed, Web of Science and Scopus, up to August 2021. Eligibility criteria included studies that analysed human biofilm formation on titanium specimens with distinct surface roughness (smooth vs minimally, moderate, or rough) over the experimental times of 1 or 3 days. Roughness average (Ra) and biofilm analysis parameters were extracted from selected articles. Risk of bias was evaluated using the Checklist for Quasi-Experimental Studies. Results Of 5286 papers, 5 were included and analysed. Smooth titanium surfaces included machined and anodized titanium/Ti-6Al-4V; machined and acid etched TiZr. Minimally, moderately, or rough surfaces comprised titanium and titanium alloys (TiZr, Ti-6Al-4V), that received surface treatments (anodization, acid-etching, blasting, hydroxyapatite-coating). No statistically significant difference on biofilm formation on rough and smooth titanium surfaces was reported by 3 studies, while more contamination on rough titanium surfaces was stated by 2 investigations. An isolated smooth surface has also been associated to higher contamination. Moderate to high quality methodological assessment of studies were identified. Conclusions It is not possible to assume that rough surfaces are more susceptible to early biofilm formation than smooth titanium surfaces. Additional studies are required to study this multifarious interaction.
【摘要】目的人们关注种植体表面粗糙度的提高是否导致了更高的生物膜形成，而生物膜形成是种植体周围疾病的病因因素。本系统综述的目的是回答以下问题:“与钛标本上光滑的表面相比，粗糙的表面是否更容易形成早期生物膜?”材料和方法本研究在PubMed, Web of Science和Scopus上进行，截止到2021年8月。合格标准包括在1或3天的实验时间内，分析具有不同表面粗糙度(光滑与最低、中等或粗糙)的钛标本上的人体生物膜形成的研究。提取所选样品的粗糙度平均值(Ra)和生物膜分析参数。使用准实验研究检查表评估偏倚风险。结果共收录5286篇论文，分析5篇。光滑钛表面包括机械加工和阳极氧化钛/Ti-6Al-4V;机加工和酸蚀TiZr。最小、中等或粗糙的表面由钛和钛合金(TiZr、Ti-6Al-4V)组成，表面处理(阳极氧化、酸蚀、喷砂、羟基磷灰石涂层)。3项研究报告粗糙和光滑钛表面生物膜形成差异无统计学意义，2项研究报告粗糙钛表面生物膜污染较多。孤立的光滑表面也与较高的污染有关。确定了中等到高质量的研究方法学评估。结论不能认为粗糙的钛表面比光滑的钛表面更容易形成早期生物膜。需要进一步的研究来研究这种多样的相互作用。
{"title":"Early Biofilm Formation on Rough and Smooth Titanium Specimens: a Systematic Review of Clinical Studies","authors":"Renata Scheeren Brum, K. Apaza-Bedoya, L. Labes, C. M. Volpato, A. Pimenta, C. Benfatti","doi":"10.5037/jomr.2021.12401","DOIUrl":"https://doi.org/10.5037/jomr.2021.12401","url":null,"abstract":"ABSTRACT Objectives There is a concern whether the enhancement on implant surface roughness is responsible for higher biofilm formation, which acts as an aetiological factor for peri-implant diseases. The aim of the present systematic review was to answer the following question: “Are rough surfaces more susceptible to early biofilm formation when compared to smoother surfaces on titanium specimens?”. Material and Methods The research was performed on PubMed, Web of Science and Scopus, up to August 2021. Eligibility criteria included studies that analysed human biofilm formation on titanium specimens with distinct surface roughness (smooth vs minimally, moderate, or rough) over the experimental times of 1 or 3 days. Roughness average (Ra) and biofilm analysis parameters were extracted from selected articles. Risk of bias was evaluated using the Checklist for Quasi-Experimental Studies. Results Of 5286 papers, 5 were included and analysed. Smooth titanium surfaces included machined and anodized titanium/Ti-6Al-4V; machined and acid etched TiZr. Minimally, moderately, or rough surfaces comprised titanium and titanium alloys (TiZr, Ti-6Al-4V), that received surface treatments (anodization, acid-etching, blasting, hydroxyapatite-coating). No statistically significant difference on biofilm formation on rough and smooth titanium surfaces was reported by 3 studies, while more contamination on rough titanium surfaces was stated by 2 investigations. An isolated smooth surface has also been associated to higher contamination. Moderate to high quality methodological assessment of studies were identified. Conclusions It is not possible to assume that rough surfaces are more susceptible to early biofilm formation than smooth titanium surfaces. Additional studies are required to study this multifarious interaction.","PeriodicalId":230885,"journal":{"name":"Journal of Oral & Maxillofacial Research","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128800847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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