Etiology of Chronic Liver Disease in Ethiopia: A Case Control Study with Special Reference to Viral Hepatitis and Alcohol.

EC gastroenterology and digestive system Pub Date : 2018-03-01 Epub Date: 2018-02-06

Semira Abdelmenan, Abate Banes, Yemane Berhane, Markos Abebe, J H Wandall

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Abstract

Introduction: Chronic diseases of the liver are a global health problem with high morbidity and mortality. Viral hepatitis is the predominant cause for liver disease in low and middle-income countries. Viral hepatitis is also frequent in high-income countries but mainly as a complication to drug abuse or iatrogenic to treatment. In high-income countries non-fatty-liver-disease and complications to alcohol consumption are the most frequent etiology of liver disease. Viral hepatitis B and C is prevalent in Ethiopia but there are only few studies done in relation to chronic liver disease and a relationship between the increasing alcohol consumption and chronic liver disease.

Objective: A The aim of the study was to assess the association between chronic liver disease in Ethiopia and infection with viral hepatitis and possible relation to alcohol consumption.

Methods and material: An unmatched case control study was conducted in Addis Ababa. Cases were chronic liver disease patients (n = 812) and controls were patients without liver disease (n = 798). Data were collected from the records of patients treated at a specialized clinic of Gastrsoenterology and Hepatology in Addis Ababa from 1^st January 2013 - 31^st, December 2013.

Results: The odds of having hepatitis infection among chronic liver disease was AOR = 100.96, (95%CI: 62.15 - 164.02) for HBV and AOR = 59.2, (95%CI: 27.23 - 130.9) for HCV. Consumption of alcohol was associated with chronic liver disease (OR: 8.23 95%CI: 3.76 - 12.70). Liver enzymes were elevated significantly in patients with hepatitis and alcohol consumption compared to patients without alcohol consumption.

Conclusion: Viral hepatitis infections are strongly associated with chronic liver disease. Prevention of viral hepatitis infections and control of alcohol consumption need to be strengthened in order to reduce the burden of chronic liver disease in Ethiopia.

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埃塞俄比亚慢性肝病的病因学:一项特别涉及病毒性肝炎和酒精的病例对照研究。

慢性肝脏疾病是一个全球性的健康问题，具有很高的发病率和死亡率。病毒性肝炎是低收入和中等收入国家肝病的主要病因。病毒性肝炎在高收入国家也很常见，但主要是药物滥用的并发症或医源性治疗。在高收入国家，非脂肪性肝病和饮酒并发症是肝病最常见的病因。病毒性乙型肝炎和丙型肝炎在埃塞俄比亚很普遍，但关于慢性肝病和不断增加的酒精消费量与慢性肝病之间关系的研究很少。目的:本研究的目的是评估埃塞俄比亚慢性肝病与病毒性肝炎感染之间的关系，并可能与饮酒有关。方法和材料:在亚的斯亚贝巴进行了一项无与伦比的病例对照研究。病例为慢性肝病患者(n = 812)，对照组为无肝病患者(n = 798)。数据收集自2013年1月1日至2013年12月31日在亚的斯亚贝巴一家胃肠病学和肝病专科诊所接受治疗的患者记录。结果:慢性肝病患者发生肝炎感染的几率，HBV为AOR = 100.96 (95%CI: 62.15 ~ 164.02)， HCV为AOR = 59.2 (95%CI: 27.23 ~ 130.9)。饮酒与慢性肝病相关(OR: 8.23 95%CI: 3.76 - 12.70)。与不饮酒的患者相比，饮酒的肝炎患者肝酶显著升高。结论:病毒性肝炎感染与慢性肝病密切相关。需要加强预防病毒性肝炎感染和控制酒精消费，以减轻埃塞俄比亚慢性肝病的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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