{"title":"Genetic Risk Factors for the Development of Periimplantitis.","authors":"Ioannis Fourmousis, Manolis Vlachos","doi":"10.1097/ID.0000000000000874","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Periimplantitis etiology is multifactorial. The aim of this review is to identify the available data so far concerning the association between genetic polymorphisms and periimplantitis risk.</p><p><strong>Materials and methods: </strong>A literature search was performed in MEDLINE using the PubMed database of the US National Library of Medicine for articles published until March 2018. In addition, a manual search was performed. Our search and application of eligibility criteria provided 23 articles. Genes in these 23 studies could be divided into 3 overlapping categories: genes associated with (a) immune function, (b) bone growth, and (c) regulation of gene expression.</p><p><strong>Discussion: </strong>The pathogenesis of periimplantitis is not currently well understood. There are some polymorphisms, for which different studies state consistent results. However, there are many polymorphisms with conflicting results, which could be attributed to differences in study design.</p><p><strong>Conclusion: </strong>The identification of genetic biomarkers associated with periimplantitis risk could be valuable in daily clinical practice. However, no robust conclusions could be drawn from the current literature. The inequality of these studies' design necessitates the conduction of further studies using larger population samples and from different ethnic groups.</p>","PeriodicalId":13309,"journal":{"name":"Implant Dentistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/ID.0000000000000874","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Implant Dentistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/ID.0000000000000874","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Dentistry","Score":null,"Total":0}
引用次数: 7
Abstract
Introduction: Periimplantitis etiology is multifactorial. The aim of this review is to identify the available data so far concerning the association between genetic polymorphisms and periimplantitis risk.
Materials and methods: A literature search was performed in MEDLINE using the PubMed database of the US National Library of Medicine for articles published until March 2018. In addition, a manual search was performed. Our search and application of eligibility criteria provided 23 articles. Genes in these 23 studies could be divided into 3 overlapping categories: genes associated with (a) immune function, (b) bone growth, and (c) regulation of gene expression.
Discussion: The pathogenesis of periimplantitis is not currently well understood. There are some polymorphisms, for which different studies state consistent results. However, there are many polymorphisms with conflicting results, which could be attributed to differences in study design.
Conclusion: The identification of genetic biomarkers associated with periimplantitis risk could be valuable in daily clinical practice. However, no robust conclusions could be drawn from the current literature. The inequality of these studies' design necessitates the conduction of further studies using larger population samples and from different ethnic groups.
期刊介绍：
Cessation. Implant Dentistry, an interdisciplinary forum for general practitioners, specialists, educators, and researchers, publishes relevant clinical, educational, and research articles that document current concepts of oral implantology in sections on biomaterials, clinical reports, oral and maxillofacial surgery, oral pathology, periodontics, prosthodontics, and research. The journal includes guest editorials, letters to the editor, book reviews, abstracts of current literature, and news of sponsoring societies.
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