Effect of Raloxifene Administration on Bone Response Around Implant in the Maxilla of Osteoporotic Rats.

3区医学 Q1 Dentistry Implant Dentistry Pub Date : 2019-06-01 DOI:10.1097/ID.0000000000000881

Hyun-A Heo, Suhyun Park, Yoon-Sik Jeon, Sung-Woon Pyo

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Abstract

Objectives: To determine the effect of raloxifene (RAL) on bone response around implants in the maxilla of osteoporotic rats.

Materials and methods: Forty-five female rats at 8 weeks-old were divided into 3 groups: (1) control group, sham-operated rats, (2) ovariectomized group (OVX), and (3) ovariectomized and raloxifene-administered group (RAL). Eight weeks after the ovariectomy, upper right molar was extracted and an implant was placed at 4 weeks post-extraction. The RAL group was administered with 1 mg/kg/d of raloxifene via gavage while the OVX group and the control group received saline only. Three rats in each group were sacrificed at 1, 4, 7, 14, and 28 days and histologic sections were evaluated by hematoxylin and eosin staining and micro-computerized tomography was taken.

Results: The RAL group showed faster bone formation around the implant than the OVX group. At 4 weeks after implantation, newly formed bone close to implant threads was mature with considerable quantity of bone marrow in the RAL group.

Conclusion: Raloxifene showed increased bone formation around implant. This might have clinical implications in prosthetic restoration by dental implants for patients with poor bone quality.

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雷洛昔芬对骨质疏松大鼠上颌骨种植体周围骨反应的影响。

目的:探讨雷洛昔芬(raloxifene, RAL)对骨质疏松大鼠上颌骨种植体周围骨反应的影响。材料与方法:8周龄雌性大鼠45只，随机分为3组:(1)对照组、假手术组、(2)去卵巢组(OVX)、(3)去卵巢加雷洛昔芬组(RAL)。卵巢切除术后8周，拔除右上磨牙，拔除后4周放置种植体。RAL组灌胃给予雷洛昔芬1 mg/kg/d, OVX组和对照组仅给予生理盐水。每组分别于第1、4、7、14、28天处死3只大鼠，采用苏木精染色、伊红染色观察组织切片，并行显微计算机断层扫描。结果:RAL组种植体周围骨形成速度快于OVX组。植入后4周，RAL组靠近种植体线的新生骨成熟，骨髓数量可观。结论:雷洛昔芬使种植体周围骨形成增加。这可能对骨质量差的患者采用牙种植体修复具有临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Implant Dentistry 医学-牙科与口腔外科

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cessation. Implant Dentistry, an interdisciplinary forum for general practitioners, specialists, educators, and researchers, publishes relevant clinical, educational, and research articles that document current concepts of oral implantology in sections on biomaterials, clinical reports, oral and maxillofacial surgery, oral pathology, periodontics, prosthodontics, and research. The journal includes guest editorials, letters to the editor, book reviews, abstracts of current literature, and news of sponsoring societies.