Does working memory improvement benefit from sleep in older adults?

Q2 Medicine Neurobiology of Sleep and Circadian Rhythms Pub Date : 2019-01-01 DOI:10.1016/j.nbscr.2019.01.001

Negin Sattari , Lauren N. Whitehurst , Maryam Ahmadi , Sara C. Mednick

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引用次数: 24

Abstract

Working Memory (WM), is an important factor influencing many higher-order cognitive functions that decline with age. Repetitive training appears to increase WM, yet the mechanisms underlying this improvement are not understood. Sleep has been shown to benefit long-term memory formation and may also play a role in WM enhancement in young adults. However, considering age-related decline in sleep, it is uninvestigated whether sleep will facilitate WM in older adults. In the present work, we investigated the impact of a nap, quiet wakefulness (QW) and active wakefulness (AW) on within-day training on the Operation Span (OSPAN) task in older adults. Improvement in WM was found following a nap and QW, but not active wake. Furthermore, better WM was associated with shared electrophysiological features, including slow oscillation (SO, 0.5–1 Hz) power in both the nap and QW, and greater coupling between SO and sigma (12–15 Hz) in the nap. In summary, our data suggest that WM improvement in older adults occurs opportunistically during offline periods that afford enhancement in slow oscillation power, and that further benefits may come with cross-frequency coupling of neural oscillations during sleep.

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老年人的工作记忆改善是否受益于睡眠?

工作记忆(WM)是影响许多随着年龄增长而下降的高阶认知功能的重要因素。重复训练似乎增加了WM，但这种改善的机制尚不清楚。睡眠已被证明有利于长期记忆的形成，也可能在年轻人的WM增强中发挥作用。然而，考虑到与年龄相关的睡眠减少，睡眠是否会促进老年人WM尚未得到研究。在本研究中，我们研究了午睡、安静清醒(QW)和主动清醒(AW)对老年人日间操作跨度(osspan)任务训练的影响。在午睡和QW后，WM有所改善，但没有主动醒来。此外，较好的WM与共同的电生理特征有关，包括小睡和QW中的慢振荡(SO, 0.5-1 Hz)功率，以及小睡中SO和sigma(12-15 Hz)之间的更大耦合。综上所述，我们的数据表明，老年人的WM改善在离线期间机会性地发生，这可以增强慢振荡功率，并且进一步的好处可能来自睡眠期间神经振荡的交叉频率耦合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Sleep and Circadian Rhythms Neuroscience-Behavioral Neuroscience

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

69 days

期刊介绍： Neurobiology of Sleep and Circadian Rhythms is a multidisciplinary journal for the publication of original research and review articles on basic and translational research into sleep and circadian rhythms. The journal focuses on topics covering the mechanisms of sleep/wake and circadian regulation from molecular to systems level, and on the functional consequences of sleep and circadian disruption. A key aim of the journal is the translation of basic research findings to understand and treat sleep and circadian disorders. Topics include, but are not limited to: Basic and translational research, Molecular mechanisms, Genetics and epigenetics, Inflammation and immunology, Memory and learning, Neurological and neurodegenerative diseases, Neuropsychopharmacology and neuroendocrinology, Behavioral sleep and circadian disorders, Shiftwork, Social jetlag.