The correlation between serum thyroid hormone levels and hand grip among elderly male Chinese inpatients.

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Aging Male Pub Date : 2020-12-01 Epub Date: 2019-07-03 DOI:10.1080/13685538.2019.1634044

Lingyan Chen, Yu Hu

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引用次数: 6

Abstract

Introduction: Thyroid dysfunction is closely associated with skeletal muscle weakness. However, data on the optimal serum range of thyroid hormones for maintaining muscle strength in the elderly is lacking.

Methods: We conducted a cross-sectional analysis in male elderly inpatients from the Geriatric Department of Zhongshan Hospital (affiliated to Fudan University, Shanghai, China). Serum biochemical parameters and thyroid hormones were detected for each participant. Hand grip (HG) was measured, with low hand grip defined as HG <26 kg according to the standard of the Asian Working Group for Sarcopenia. Logistic regression was used to evaluate the effects of different serum thyroid hormone levels on HG.

Results: The majority of the subjects were euthyroid. The prevalence of low hand grip was 48.5%. Stratified by the free thyroxine (FT4) quartiles, the results showed HG was the highest in the third quartile. Multiple logistic regression analysis showed that compared with those in the first quartile, subjects in the third quartile of FT4 had a significantly lower risk of low hand grip (OR = 0.133, 95%CI: 0.020-0.610, p = .009), after adjusting potential confounding factors.

Conclusion: In elderly male inpatients, maintaining a narrower serum range of thyroid hormone might be needed to protect skeletal muscle strength.

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老年男性住院患者血清甲状腺激素水平与握力的相关性研究。

甲状腺功能障碍与骨骼肌无力密切相关。然而，关于维持老年人肌肉力量的甲状腺激素的最佳血清范围的数据缺乏。方法:对复旦大学附属中山医院老年科住院的男性老年患者进行横断面分析。检测每位受试者的血清生化指标和甲状腺激素。测量了手握力(HG)，将低手握力定义为HG结果:大多数受试者甲状腺功能正常。低握手率为48.5%。按游离甲状腺素(FT4)四分位数分层，结果显示HG在第三四分位数最高。多元logistic回归分析显示，在调整潜在混杂因素后，FT4的第三四分位受试者的低握力风险显著低于第一四分位受试者(OR = 0.133, 95%CI: 0.020-0.610, p = 0.009)。结论:在老年男性住院患者中，维持较窄的血清甲状腺激素范围可能是保护骨骼肌力量的必要条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.