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The efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) in treating erectile dysfunction: a systematic review and meta-analysis of seven randomized controlled trials.
IF 2.7 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-12-01 Epub Date: 2025-03-04 DOI: 10.1080/13685538.2025.2472786
Zhongbao Zhou, Yongqiang Wang, Yumeng Chai, Tao Wang, Pu Yan, Yong Zhang, Xudong Yang

Background: The goal of this meta-analysis intended to identify the efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) as a therapy for erectile dysfunction (ED).

Methods: This study integrated and analyzed the data using Cochrane method and GRADEpro GDT grading system. The registration number for this study was CRD42024618240.

Result: Seven randomized controlled trials with 660 patients were analyzed. The results indicated that compared with the control group, IIEF score of patients in the PRP group improved significantly at 12-week (p = 0.03) and 24-week (p = 0.0004), while there was no significant difference at 4-week. The PRP group had no significant advantages over the control group in terms of MCID and SEP Q3. For peak systolic velocity, patients in the PRP group demonstrated greater improvement than those in the control group (p < 0.00001). Subgroup analysis revealed that adding PRP regimen can considerably improve IIEF scores of ED patients compared to using Li-SWT alone (p < 0.0001).

Conclusion: PRP demonstrated a better efficacy in treating ED, especially during a follow-up period of 6 months. Compared with using Li-SWT alone, the addition of PRP can considerably improve the IIEF score of ED patients. These findings still required large-scale clinical trials for verification.

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引用次数: 0
Artificial urinary sphincter implantation after transperineal open reconstruction of post-prostatectomy vesicourethral anastomotic stenosis. 前列腺切除术后膀胱尿道吻合口狭窄经会阴开放性重建术后人工尿道括约肌植入术。
IF 2.7 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-12-01 Epub Date: 2024-12-10 DOI: 10.1080/13685538.2024.2436862
Phillip Marks, Roland Dahlem, Margit Fisch, Victor M Schuettfort, Malte W Vetterlein, Dejan K Filipas, Tim A Ludwig

Purpose: This study evaluates the effectiveness of artificial urinary sphincter (AUS) implantation following transperineal reanastomosis in men with vesicourethral anastomotic stenosis (VUAS) and stress urinary incontinence (SUI) after radical prostatectomy (RP), focusing on long-term explantation rates and urinary continence.

Methods: Patients treated between 2009 and 2020 were retrospectively analyzed. Those undergoing AUS implantation post-transperineal reanastomosis for recurrent VUAS, excluding cases with prior pelvic irradiation and overactive bladder, were included. Primary outcomes were AUS explantation rates and patient-reported continence. Median follow-up was calculated using reverse Kaplan-Meier estimates, and explantation-free survival illustrated via Kaplan-Meier analyses.

Results: At final follow-up, 19 patients were included at a median follow-up of 79 months. Explantation occurred in 16% (N = 3) of cases, with a median time to explantation of 107 months. No urethral erosion was observed. Explantation-free survival at 2, 5, and 10 years was 100%, 87%, and 73%, respectively. The median number of pads/day decreased significantly postoperatively, with 78% (N = 14) reporting subjective continence and 89% (N = 16) achieving social continence.

Conclusion: AUS implantation following transperineal reanastomosis for VUAS post-RP offers favorable long-term outcomes, with low explantation rates and no erosion, making it a viable management strategy.

目的:评价膀胱尿道吻合口狭窄(VUAS)和压力性尿失禁(SUI)男性根治性前列腺切除术(RP)后经会阴再吻合后人工尿道括约肌(AUS)植入术的疗效,重点观察植入率和尿失禁情况。方法:对2009 ~ 2020年收治的患者进行回顾性分析。除既往盆腔照射和膀胱过度活动的病例外,复发性vas经会阴再吻合术后行AUS植入者纳入研究。主要结果是AUS的外植率和患者报告的尿失禁。中位随访使用反向Kaplan-Meier估计计算,无解释生存率通过Kaplan-Meier分析说明。结果:最终随访时,19例患者纳入,中位随访79个月。16% (N = 3)的病例脱植,平均脱植时间为107个月。未见尿道糜烂。2年、5年和10年的无解释生存率分别为100%、87%和73%。术后尿垫/天的中位数显著下降,78% (N = 14)报告主观控制,89% (N = 16)达到社会控制。结论:经会阴吻合术后植入术长期效果良好,植入率低,无糜烂,是一种可行的治疗策略。
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引用次数: 0
Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study. 40岁及以上男性内脏脂肪指数与前列腺癌之间的关系:一项全国性横断面研究。
IF 2.7 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-12-01 Epub Date: 2025-01-08 DOI: 10.1080/13685538.2024.2449341
Wentao Yao, Jiacheng Wu, Hongzhi Wang, Zongming Jia, Yinyi Zhou, Chendi Yang, Feng Xu, Ying Kong, Yuhua Huang

Objectives: This study aimed to elucidate the correlation of Visceral Adiposity Index (VAI) with prostate cancer (PCa) among men aged 40 years and older in the United States.

Methods: Analysis included multivariate linear and logistic regression, smoothing curve fitting, and threshold effect evaluation using 2003-2010 National Health and Nutrition Examination Survey (NHANES) data. The stability of this relationship across demographic groups was assessed via subgroup analyses and interaction tests.

Results: Among 2,768 participants, those with elevated VAI displayed lower total prostate-specific antigen (tPSA) levels and reduced PCa risk. Each VAI unit elevation corresponded to a 0.075 ng/mL tPSA reduction [-0.075 (-0.145, -0.005)] and 18.8% PCa risk reduction [0.812 (0.687, 0.960)]. Top-quartile VAI individuals exhibited 0.282 ng/mL reduced tPSA [-0.282 (-0.557, -0.007)] and 49.7% reduced PCa risk [0.503 (0.282, 0.896)] relative to bottom-quartile counterparts. This inverse relationship was more pronounced in men ≥70 years. Moreover, VAI-tPSA in other races demonstrated a U-shaped pattern, with a 2.09 inflection point. At the same time, a Mexican American subgroup exhibited an inverted U-shape for VAI and PCa risk, with a 1.42 inflection point.

Conclusion: In men aged ≥70, VAI indicates an inverse PCa relationship. However, PSA-based PCa screening may be influenced in visceral-obese individuals aged <70.

目的:本研究旨在阐明美国40岁及以上男性的内脏脂肪指数(VAI)与前列腺癌(PCa)的相关性。方法:采用2003-2010年全国健康与营养调查(NHANES)数据进行多元线性和logistic回归分析、平滑曲线拟合和阈值效应评价。通过亚组分析和相互作用测试评估了人口统计学组间这种关系的稳定性。结果:在2768名参与者中,VAI升高的患者表现出较低的总前列腺特异性抗原(tPSA)水平和较低的PCa风险。每升高一个VAI单位,tPSA降低0.075 ng/mL[-0.075(-0.145, -0.005)],前列腺癌风险降低18.8%[0.812(0.687,0.960)]。与最低四分位数的VAI个体相比,最高四分位数的VAI个体的tPSA降低了0.282 ng/mL [-0.282 (-0.557, -0.007)], PCa风险降低了49.7%[0.503(0.282,0.896)]。这种负相关关系在≥70岁的男性中更为明显。其他种族的VAI-tPSA呈u型分布,拐点为2.09。与此同时,墨西哥裔美国人的VAI和PCa风险呈倒u型,拐点为1.42。结论:在≥70岁的男性中,VAI与PCa呈负相关。然而,基于psa的前列腺癌筛查可能会影响年龄较大的内脏肥胖个体
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引用次数: 0
Risk factors influencing fall risk in geriatric patients with type 2 diabetes: a comprehensive analysis.
IF 2.7 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-12-01 Epub Date: 2025-03-01 DOI: 10.1080/13685538.2025.2469614
Muharrem Bayrak, Kamber Kaşali, Merve Güner, Kenan Cadirci, Adil Furkan Kılıç, Dogan Nasır Binici

Background and objectives: Type 2 diabetes mellitus (T2DM) is a common chronic disease in the elderly. Comorbidities, especially neuropathy and retinopathy, significantly increase fall risk in this group. This study aimed to identify fall risk factors in older adults with T2DM.

Materials and methods: From January to June 2024, 242 T2DM patients aged 65 and older were followed at the internal medicine outpatient clinic. Fall risk was assessed using the Performance Oriented Mobility Assessment (POMA), Hendrich II Fall Risk Model (HIIFRM), Barthel Activities of Daily Living Index, and Clinical Frailty Scale (CFS).

Results: Among the patients (median age = 70 years), 41.3% had experienced at least one fall in the previous year. Factors, such as age and diabetes duration were associated with falls. Notably, hypoglycemia (aPR: 1.90, p = 0.017), polypharmacy (aPR: 2.39, p = 0.004), osteoarthritis (aPR: 2.48, p = 0.017), (aPR: 1.70, p = 0.025), and malnutrition (aPR: 1.90, p = 0.007) were independently associated with fall risk.

Conclusions: Fall risk in elderly outpatients with T2DM was linked to various factors, including hospitalization, malnutrition, osteoarthritis, polypharmacy, neuropathy, and hypoglycemia. To mitigate this risk, patient-specific care plans are recommended.

{"title":"Risk factors influencing fall risk in geriatric patients with type 2 diabetes: a comprehensive analysis.","authors":"Muharrem Bayrak, Kamber Kaşali, Merve Güner, Kenan Cadirci, Adil Furkan Kılıç, Dogan Nasır Binici","doi":"10.1080/13685538.2025.2469614","DOIUrl":"https://doi.org/10.1080/13685538.2025.2469614","url":null,"abstract":"<p><strong>Background and objectives: </strong>Type 2 diabetes mellitus (T2DM) is a common chronic disease in the elderly. Comorbidities, especially neuropathy and retinopathy, significantly increase fall risk in this group. This study aimed to identify fall risk factors in older adults with T2DM.</p><p><strong>Materials and methods: </strong>From January to June 2024, 242 T2DM patients aged 65 and older were followed at the internal medicine outpatient clinic. Fall risk was assessed using the Performance Oriented Mobility Assessment (POMA), Hendrich II Fall Risk Model (HIIFRM), Barthel Activities of Daily Living Index, and Clinical Frailty Scale (CFS).</p><p><strong>Results: </strong>Among the patients (median age = 70 years), 41.3% had experienced at least one fall in the previous year. Factors, such as age and diabetes duration were associated with falls. Notably, hypoglycemia (aPR: 1.90, <i>p</i> = 0.017), polypharmacy (aPR: 2.39, <i>p</i> = 0.004), osteoarthritis (aPR: 2.48, <i>p</i> = 0.017), (aPR: 1.70, <i>p</i> = 0.025), and malnutrition (aPR: 1.90, <i>p</i> = 0.007) were independently associated with fall risk.</p><p><strong>Conclusions: </strong>Fall risk in elderly outpatients with T2DM was linked to various factors, including hospitalization, malnutrition, osteoarthritis, polypharmacy, neuropathy, and hypoglycemia. To mitigate this risk, patient-specific care plans are recommended.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2469614"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preservation of sexual function with blue laser vaporization in the treatment of benign prostatic hyperplasia: a prospective study.
IF 2.7 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-12-01 Epub Date: 2025-03-04 DOI: 10.1080/13685538.2025.2473609
Zun-Jie Hu, Fei Liu, Bing-Hui Li, Yan Hu, Qiao Huang, Cong Zhu, Xian-Tao Zeng, Yong-Wei Zhao

Objective: Sexual function preservation is a paramount concern for patients undergoing benign prostatic hyperplasia (BPH) surgery, increasingly recognized by physicians. Blue laser vaporization, a novel approach for BPH treatment, has yet to be thoroughly investigated for its effects on sexual function. This prospective study assesses the impact of blue laser vaporization on sexual function in BPH patients, focusing on patient perceptions.

Methods: This study prospectively enrolled BPH patients undergoing blue laser vaporization at our hospital since January 2023. We evaluated the treatment's effectiveness and its impact on preserving sexual function using standardized questionnaires. These included the International Index of Erectile Function (IIEF-5), the Male Sexual Health Questionnaire for Ejaculatory Dysfunction (MSHQ-EjD), and both the International Consultation on Incontinence Modular Questionnaire for Male Lower Urinary Tract Symptoms (ICIQ-MLUTS) and its sexual function component (ICIQ-MLUTSsex).

Results: We included 67 BPH patients with a median age of 65 years in this study, monitoring them for over three months. The results indicate that blue laser vaporization significantly improved International Prostate Symptom Score, Quality of Life, and ICIQ-MLUTS scores in BPH patients (p < 0.001), along with a reduction in post-void residual volume (p < 0.001). Importantly, there were no significant changes in the IIEF-5 score, MSHQ-EjD score, and ICIQ-MLUTSsex score, indicating preservation of sexual function post-surgery.

Conclusion: Blue laser vaporization effectively alleviates lower urinary tract symptoms in BPH patients while preserving erectile and ejaculatory functions.

{"title":"Preservation of sexual function with blue laser vaporization in the treatment of benign prostatic hyperplasia: a prospective study.","authors":"Zun-Jie Hu, Fei Liu, Bing-Hui Li, Yan Hu, Qiao Huang, Cong Zhu, Xian-Tao Zeng, Yong-Wei Zhao","doi":"10.1080/13685538.2025.2473609","DOIUrl":"https://doi.org/10.1080/13685538.2025.2473609","url":null,"abstract":"<p><strong>Objective: </strong>Sexual function preservation is a paramount concern for patients undergoing benign prostatic hyperplasia (BPH) surgery, increasingly recognized by physicians. Blue laser vaporization, a novel approach for BPH treatment, has yet to be thoroughly investigated for its effects on sexual function. This prospective study assesses the impact of blue laser vaporization on sexual function in BPH patients, focusing on patient perceptions.</p><p><strong>Methods: </strong>This study prospectively enrolled BPH patients undergoing blue laser vaporization at our hospital since January 2023. We evaluated the treatment's effectiveness and its impact on preserving sexual function using standardized questionnaires. These included the International Index of Erectile Function (IIEF-5), the Male Sexual Health Questionnaire for Ejaculatory Dysfunction (MSHQ-EjD), and both the International Consultation on Incontinence Modular Questionnaire for Male Lower Urinary Tract Symptoms (ICIQ-MLUTS) and its sexual function component (ICIQ-MLUTSsex).</p><p><strong>Results: </strong>We included 67 BPH patients with a median age of 65 years in this study, monitoring them for over three months. The results indicate that blue laser vaporization significantly improved International Prostate Symptom Score, Quality of Life, and ICIQ-MLUTS scores in BPH patients (<i>p</i> < 0.001), along with a reduction in post-void residual volume (<i>p</i> < 0.001). Importantly, there were no significant changes in the IIEF-5 score, MSHQ-EjD score, and ICIQ-MLUTSsex score, indicating preservation of sexual function post-surgery.</p><p><strong>Conclusion: </strong>Blue laser vaporization effectively alleviates lower urinary tract symptoms in BPH patients while preserving erectile and ejaculatory functions.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2473609"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of testicular histopathology with sperm retrieval success rates in men with idiopathic non-obstructive azoospermia. 特发性非梗阻性无精子症男性睾丸组织病理学与取精成功率的关系。
IF 2.7 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-12-01 Epub Date: 2024-12-14 DOI: 10.1080/13685538.2024.2436850
Thang Nguyen Cao, Bac Nguyen Hoai, Viet Dinh Huu, Emmanuele A Jannini

Introduction: Infertility is a major public health issue, with male factors alone contributing to 20-30% of cases. Non-obstructive azoospermia (NOA) is the most severe form, and although techniques like microdissection testicular sperm extraction (mTESE) offer hope, it remains challenging due to its uncertain causes. This study investigates the correlation between testicular histopathology and clinical parameters to enhance sperm retrieval (SR) prediction.

Materials and methods: We reviewed 57 azoospermic men from Hanoi Medical University Hospital, recruited between January 2021 and September 2023. Inclusion criteria were confirmed azoospermia and exclusion of known NOA causes. All underwent mTESE with testicular biopsies classified into four histopathological patterns.

Results: The patients' mean age was 31.75 ± 5.19 years. SR was successful in 19.3% (11/57). Higher follicle-stimulating hormone (FSH) levels were noted in SR-positive men (p = 0.02). Sertoli cell-only syndrome (SCOS) was the most common pattern. While we found a significant difference in SR rate between testicular histopathology, multivariate analysis showed no strong association. However, FSH levels were predictive of histopathology patterns.

Conclusions: Idiopathic NOA (iNOA) represents over 60% of azoospermia cases. mTESE remains the gold standard, and FSH levels may help predict testicular histopathology patterns and improving patients prognosis of SR outcomes.

导言不育症是一个重大的公共卫生问题,仅男性因素就导致了20%-30%的不育症。非梗阻性无精子症(NOA)是最严重的无精子症,尽管显微解剖睾丸取精术(mTESE)等技术给人们带来了希望,但由于其病因不明确,仍具有挑战性。本研究探讨了睾丸组织病理学与临床参数之间的相关性,以加强取精(SR)预测:我们回顾了河内医科大学医院在 2021 年 1 月至 2023 年 9 月期间招募的 57 名无精症男性。纳入标准为确诊无精子症并排除已知的无精子症原因。所有患者均接受了 mTESE,睾丸活检分为四种组织病理学模式:患者的平均年龄为 31.75±5.19 岁。19.3%的患者(11/57)成功实施了SR。SR阳性男性的卵泡刺激素(FSH)水平较高(p = 0.02)。仅有肥大细胞综合征(SCOS)是最常见的模式。虽然我们发现不同睾丸组织病理学的 SR 率存在显著差异,但多变量分析显示两者之间并无密切联系。然而,FSH水平可预测组织病理学模式:特发性无精子症(iNOA)占无精子症病例的60%以上。mTESE仍是金标准,而FSH水平可能有助于预测睾丸组织病理学模式,改善患者SR结果的预后。
{"title":"Association of testicular histopathology with sperm retrieval success rates in men with idiopathic non-obstructive azoospermia.","authors":"Thang Nguyen Cao, Bac Nguyen Hoai, Viet Dinh Huu, Emmanuele A Jannini","doi":"10.1080/13685538.2024.2436850","DOIUrl":"https://doi.org/10.1080/13685538.2024.2436850","url":null,"abstract":"<p><strong>Introduction: </strong>Infertility is a major public health issue, with male factors alone contributing to 20-30% of cases. Non-obstructive azoospermia (NOA) is the most severe form, and although techniques like microdissection testicular sperm extraction (mTESE) offer hope, it remains challenging due to its uncertain causes. This study investigates the correlation between testicular histopathology and clinical parameters to enhance sperm retrieval (SR) prediction.</p><p><strong>Materials and methods: </strong>We reviewed 57 azoospermic men from Hanoi Medical University Hospital, recruited between January 2021 and September 2023. Inclusion criteria were confirmed azoospermia and exclusion of known NOA causes. All underwent mTESE with testicular biopsies classified into four histopathological patterns.</p><p><strong>Results: </strong>The patients' mean age was 31.75 ± 5.19 years. SR was successful in 19.3% (11/57). Higher follicle-stimulating hormone (FSH) levels were noted in SR-positive men (<i>p</i> = 0.02). Sertoli cell-only syndrome (SCOS) was the most common pattern. While we found a significant difference in SR rate between testicular histopathology, multivariate analysis showed no strong association. However, FSH levels were predictive of histopathology patterns.</p><p><strong>Conclusions: </strong>Idiopathic NOA (iNOA) represents over 60% of azoospermia cases. mTESE remains the gold standard, and FSH levels may help predict testicular histopathology patterns and improving patients prognosis of SR outcomes.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2436850"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older people. 家族性低钙血症高钙血症的单一病例报告:老年人高钙血症的罕见诊断。
IF 2.7 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-12-01 Epub Date: 2024-12-09 DOI: 10.1080/13685538.2024.2436877
Etienne Ojardias, Mélanie Leman, Ludovic Lafaie, Philippe Oriol, Paul Calmels, Thomas Celarier

Objective: to report a case of familial hypocalciuric hypercalcemia (FHH) in an older patient and highlight the diagnostic challenges in geriatric populations.

Case presentation: We report the diagnosis of FHH in an 88-year-old polypathological patient with hypercalcemia discovered during a check-up for cardiac decompensation. Despite a confusing clinical presentation with gout symptoms, including repeated episodes of knee arthritis, persistent hypercalcemia conducted further investigations. Biological tests excluded primary or hyperparathyroidism and malignancy-related hyperparathyroidism, confirming the diagnosis of FHH through the detection of an inhibitory mutation in the calcium-sensing receptor gene.

Conclusion: This case suggests to clinicians the possibility of FHH in older patients with unexplained hypercalcemia. In geriatric patients, the diagnosis is complicated because of the poly-pathology: here hypercalcemia was associated with a confusing gout crisis, which was triggered by diuretic treatment for heart failure.

目的:报告一例老年患者家族性低钙尿症高钙血症(FHH)的病例,并强调老年患者的诊断难题:我们报告了一名 88 岁的多病因患者的家族性高钙血症诊断结果,该患者在一次心脏失代偿检查中被发现患有高钙血症。尽管痛风症状的临床表现令人困惑,包括反复发作的膝关节炎,但持续的高钙血症使患者不得不接受进一步检查。生物检测排除了原发性或甲状旁腺功能亢进症以及恶性肿瘤相关的甲状旁腺功能亢进症,通过检测钙传感受体基因的抑制性突变,确诊为FHH:结论:本病例提示临床医生,不明原因的高钙血症老年患者可能患有FHH。在老年患者中,由于多病理因素,诊断变得复杂:本例患者的高钙血症与痛风危象有关,而痛风危象又是由治疗心力衰竭的利尿剂引发的。
{"title":"Singular case report of familial hypocalciuric hypercalcemia: a rare diagnosis of hypercalcemia in the older people.","authors":"Etienne Ojardias, Mélanie Leman, Ludovic Lafaie, Philippe Oriol, Paul Calmels, Thomas Celarier","doi":"10.1080/13685538.2024.2436877","DOIUrl":"https://doi.org/10.1080/13685538.2024.2436877","url":null,"abstract":"<p><strong>Objective: </strong>to report a case of familial hypocalciuric hypercalcemia (FHH) in an older patient and highlight the diagnostic challenges in geriatric populations.</p><p><strong>Case presentation: </strong>We report the diagnosis of FHH in an 88-year-old polypathological patient with hypercalcemia discovered during a check-up for cardiac decompensation. Despite a confusing clinical presentation with gout symptoms, including repeated episodes of knee arthritis, persistent hypercalcemia conducted further investigations. Biological tests excluded primary or hyperparathyroidism and malignancy-related hyperparathyroidism, confirming the diagnosis of FHH through the detection of an inhibitory mutation in the calcium-sensing receptor gene.</p><p><strong>Conclusion: </strong>This case suggests to clinicians the possibility of FHH in older patients with unexplained hypercalcemia. In geriatric patients, the diagnosis is complicated because of the poly-pathology: here hypercalcemia was associated with a confusing gout crisis, which was triggered by diuretic treatment for heart failure.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2436877"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive value of systemic inflammatory response index in patients with erectile dysfunction on tadalafil unresponsive patients.
IF 2.7 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-12-01 Epub Date: 2025-02-19 DOI: 10.1080/13685538.2025.2467157
Resul Sobay

Background: Erectile dysfunction (ED) is a common disorder that significantly impacts quality of life, and phosphodiesterase type 5 inhibitors (PDE5is) such as tadalafil are one of the primary treatments. However, some patients remain unresponsive, necessitating further investigation.

Objective: To investigate the association between systemic inflammatory response index (SIRI) and tadalafil unresponsiveness in erectile dysfunction patients.

Methods: A total of 106 male patients who applied to the Andrology outpatient clinic with ED complaints between January and June 2024 were included in the study. Patients were started on daily tadalafil 5 mg therapy, and response was assessed after one month using the International Index of Erectile Function Erectile Function domain (IIEF-EF). SIRI values, calculated using neutrophil, monocyte, and lymphocyte counts, were compared between tadalafil-responsive and unresponsive groups.

Results: Tadalafil unresponsiveness was observed in 48.1% of patients. Non-responders had significantly higher mean age(57.44 ± 12.52 vs. 47.22 ± 11.49, p < 0.001), BMI(27.22 ± 3.17 vs. 25.85 ± 2.92, p = 0.023), and SIRI values(1.33 ± 0.82 vs. 1.02 ± 0.40, p = 0.016) compared to responders. Multivariate analysis identified age(OR = 1,641, p = 0.001) and SIRI(OR = 2.420, p = 0.014) as independent predictors of tadalafil failure. ROC curve analysis revealed a SIRI cutoff of 1.03 (AUC = 0.617) with 69.1% sensitivity and 61.2% specificity.

Conclusion: Findings suggest that systemic inflammation plays a key role in ED pathophysiology and may impair PDE5i efficacy.

{"title":"Predictive value of systemic inflammatory response index in patients with erectile dysfunction on tadalafil unresponsive patients.","authors":"Resul Sobay","doi":"10.1080/13685538.2025.2467157","DOIUrl":"https://doi.org/10.1080/13685538.2025.2467157","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) is a common disorder that significantly impacts quality of life, and phosphodiesterase type 5 inhibitors (PDE5is) such as tadalafil are one of the primary treatments. However, some patients remain unresponsive, necessitating further investigation.</p><p><strong>Objective: </strong>To investigate the association between systemic inflammatory response index (SIRI) and tadalafil unresponsiveness in erectile dysfunction patients.</p><p><strong>Methods: </strong>A total of 106 male patients who applied to the Andrology outpatient clinic with ED complaints between January and June 2024 were included in the study. Patients were started on daily tadalafil 5 mg therapy, and response was assessed after one month using the International Index of Erectile Function Erectile Function domain (IIEF-EF). SIRI values, calculated using neutrophil, monocyte, and lymphocyte counts, were compared between tadalafil-responsive and unresponsive groups.</p><p><strong>Results: </strong>Tadalafil unresponsiveness was observed in 48.1% of patients. Non-responders had significantly higher mean age(57.44 ± 12.52 vs. 47.22 ± 11.49, <i>p</i> < 0.001), BMI(27.22 ± 3.17 vs. 25.85 ± 2.92, <i>p</i> = 0.023), and SIRI values(1.33 ± 0.82 vs. 1.02 ± 0.40, <i>p</i> = 0.016) compared to responders. Multivariate analysis identified age(OR = 1,641, <i>p</i> = 0.001) and SIRI(OR = 2.420, <i>p</i> = 0.014) as independent predictors of tadalafil failure. ROC curve analysis revealed a SIRI cutoff of 1.03 (AUC = 0.617) with 69.1% sensitivity and 61.2% specificity.</p><p><strong>Conclusion: </strong>Findings suggest that systemic inflammation plays a key role in ED pathophysiology and may impair PDE5i efficacy.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2467157"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the association between consumption of different types of beverages and erectile dysfunction in US men: evidence from NHANES 2003-2004 data. 探索美国男性饮用不同类型饮料与勃起功能障碍之间的关系:来自2003-2004年NHANES数据的证据。
IF 2.7 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-12-01 Epub Date: 2024-12-10 DOI: 10.1080/13685538.2024.2438821
Liwei Wu, Bing Li, Hang Zhou, Xiaoqiang Liu

Background: The aim of this study was to examine the relationship between the type/frequency of consuming beverages and ED among men in America.

Methods: We used data on erectile function and the frequency of beverage consumption from the National Health and Nutrition Examination Survey (NHANES) 2003-2004. Associations between ED and beverage consumption were analyzed using univariate and multivariate logistic regression. We also stratified by age and adjusted for potential confounders using propensity score matching (PSM).

Results: After fully adjusting for covariates, logistic regression showed that regular grape juice consumption (≥ 5 times/week) was related to a lower prevalence of ED (OR = 0.21, 95% CI: 0.08-0.54, p = 0.001). Subgroup analyses found that this correlation remained significant for those over 40 years of age (all p < 0.05). After PSM adjustment, the association between grape juice consumption and ED remained statistically significant (OR = 0.12, 95% CI: 0.03-0.44, p = 0.001). Various beverage types, encompassing tomato, orange, apple, pineapple, and lemonade juices, as well as soft drinks, exhibited a correlation with ED in the initial univariate regression analysis.

Conclusions: In men, regular intake of grape juice (≥ 5 times/week) was associated with a lower prevalence of ED, which was particularly significant in men over 40 years of age.

背景:本研究的目的是研究美国男性饮用饮料的类型/频率与ED之间的关系。方法:我们使用2003-2004年国家健康与营养检查调查(NHANES)中关于勃起功能和饮料消费频率的数据。使用单变量和多变量逻辑回归分析ED和饮料消费之间的关系。我们还按年龄分层,并使用倾向评分匹配(PSM)调整潜在的混杂因素。结果:在充分调整协变量后,logistic回归显示,经常饮用葡萄汁(≥5次/周)与ED患病率降低相关(OR = 0.21, 95% CI: 0.08-0.54, p = 0.001)。亚组分析发现,这种相关性在40岁以上的人群中仍然显著(所有p p = 0.001)。在最初的单变量回归分析中,包括番茄、橙子、苹果、菠萝、柠檬汁和软饮料在内的各种饮料类型都与ED存在相关性。结论:在男性中,定期摄入葡萄汁(≥5次/周)与ED患病率降低相关,这在40岁以上的男性中尤为显著。
{"title":"Exploring the association between consumption of different types of beverages and erectile dysfunction in US men: evidence from NHANES 2003-2004 data.","authors":"Liwei Wu, Bing Li, Hang Zhou, Xiaoqiang Liu","doi":"10.1080/13685538.2024.2438821","DOIUrl":"https://doi.org/10.1080/13685538.2024.2438821","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to examine the relationship between the type/frequency of consuming beverages and ED among men in America.</p><p><strong>Methods: </strong>We used data on erectile function and the frequency of beverage consumption from the National Health and Nutrition Examination Survey (NHANES) 2003-2004. Associations between ED and beverage consumption were analyzed using univariate and multivariate logistic regression. We also stratified by age and adjusted for potential confounders using propensity score matching (PSM).</p><p><strong>Results: </strong>After fully adjusting for covariates, logistic regression showed that regular grape juice consumption (≥ 5 times/week) was related to a lower prevalence of ED (OR = 0.21, 95% CI: 0.08-0.54, <i>p</i> = 0.001). Subgroup analyses found that this correlation remained significant for those over 40 years of age (all <i>p</i> < 0.05). After PSM adjustment, the association between grape juice consumption and ED remained statistically significant (OR = 0.12, 95% CI: 0.03-0.44, <i>p</i> = 0.001). Various beverage types, encompassing tomato, orange, apple, pineapple, and lemonade juices, as well as soft drinks, exhibited a correlation with ED in the initial univariate regression analysis.</p><p><strong>Conclusions: </strong>In men, regular intake of grape juice (≥ 5 times/week) was associated with a lower prevalence of ED, which was particularly significant in men over 40 years of age.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2438821"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sperm DNA damage and disturbed chromatin condensation indexes (DFI and CMA3) in normozoospermic men with unexplained infertility problem.
IF 2.7 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-12-01 Epub Date: 2025-03-10 DOI: 10.1080/13685538.2025.2472774
Mehdi Abedinzadeh, Sara Abedinzadeh, Fatemeh Sadeghi-Nodoushan, Fatemeh Pourrajab

Purpose: The quantitatively measured sperm DNA damage and disturbed chromatin condensation indexes (%DNA fragmentation index [DFI%] and %high DNA staining index [%HDS]) and their relationships with sperm quality in normospermic men with unexplained infertility were investigated. The aim was also highlighting the impact of age on both DFI and CMA3 staining and on sperm quality, and their associations with male infertility.

Methods: In this retrospective study, conventional semen tests, including sperm motility and morphological evaluations and DFI and disturbed chromatin condensation indexes (DFI, CMA3) were performed according to the World Health Organization (WHO) 2021 criteria. DFI and CMA3 were evaluated using sperm chromatin dispersion (SCD) and chromomycin A3 (CMA3) staining assays and then correlation and regression analysis were done.

Results: By analyzing SCD and CMA3 results, notable differences were found in sperm parameters among different DFI and CMA3 groups (all p < 0.05). It was found that in the male fertility quality sperm concentration, progressive (PR)/non-progressive (NP) motility, immobility, and morphology were significantly associated with sperm DFI and CMA3, but not with age (p < 0.05).

Conclusions: Sperm molecular index DFI and CMA3 negatively affect male fertility quality through semen parameters (sperm concentration, motility, and morphology). SCD and CMA3 indexes show a significant negative correlation with sperm quality in normospermic males, which highlights its role in the assessment of male fertility potential and molecular evaluation of infertility treatment.

{"title":"Sperm DNA damage and disturbed chromatin condensation indexes (DFI and CMA3) in normozoospermic men with unexplained infertility problem.","authors":"Mehdi Abedinzadeh, Sara Abedinzadeh, Fatemeh Sadeghi-Nodoushan, Fatemeh Pourrajab","doi":"10.1080/13685538.2025.2472774","DOIUrl":"https://doi.org/10.1080/13685538.2025.2472774","url":null,"abstract":"<p><strong>Purpose: </strong>The quantitatively measured sperm DNA damage and disturbed chromatin condensation indexes (%DNA fragmentation index [DFI%] and %high DNA staining index [%HDS]) and their relationships with sperm quality in normospermic men with unexplained infertility were investigated. The aim was also highlighting the impact of age on both DFI and CMA3 staining and on sperm quality, and their associations with male infertility.</p><p><strong>Methods: </strong>In this retrospective study, conventional semen tests, including sperm motility and morphological evaluations and DFI and disturbed chromatin condensation indexes (DFI, CMA3) were performed according to the World Health Organization (WHO) 2021 criteria. DFI and CMA3 were evaluated using sperm chromatin dispersion (SCD) and chromomycin A3 (CMA3) staining assays and then correlation and regression analysis were done.</p><p><strong>Results: </strong>By analyzing SCD and CMA3 results, notable differences were found in sperm parameters among different DFI and CMA3 groups (all <i>p</i> < 0.05). It was found that in the male fertility quality sperm concentration, progressive (PR)/non-progressive (NP) motility, immobility, and morphology were significantly associated with sperm DFI and CMA3, but not with age (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Sperm molecular index DFI and CMA3 negatively affect male fertility quality through semen parameters (sperm concentration, motility, and morphology). SCD and CMA3 indexes show a significant negative correlation with sperm quality in normospermic males, which highlights its role in the assessment of male fertility potential and molecular evaluation of infertility treatment.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":"28 1","pages":"2472774"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Aging Male
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