The ammonia-lyases: enzymes that use a wide range of approaches to catalyze the same type of reaction.

IF 6.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2019-12-01 Epub Date: 2020-01-06 DOI:10.1080/10409238.2019.1708261

Ronald E Viola

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引用次数: 1

Abstract

Abstract The paradigm that protein structure determines protein function has been clearly established. What is less clear is whether a specific protein structure is always required to carry out a specific function. Numerous cases are now known where there is no apparent connection between the biological function of a protein and the other members of its structural class, and where functionally related proteins can have quite diverse structures. A set of enzymes with these diverse properties, the ammonia-lyases, will be examined in this review. These are a class of enzymes that catalyze a relatively straightforward deamination reaction. However, the individual enzymes of this class possess a wide variety of different structures, utilize a diverse set of cofactors, and appear to catalyze this related reaction through a range of different mechanisms. This review aims to address a basic question: if there is not a specific protein structure and active site architecture that is both required and sufficient to define a catalyst for a given chemical reaction, then what factor(s) determine the structure and the mechanism that is selected to catalyze a particular reaction?

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氨解酶:使用多种方法催化同一类型反应的酶。

蛋白质结构决定蛋白质功能的范式已被明确确立。不太清楚的是，特定的蛋白质结构是否总是需要执行特定的功能。目前已知的许多情况下，一种蛋白质的生物学功能与其结构类的其他成员之间没有明显的联系，而功能相关的蛋白质可能具有相当不同的结构。本文将对具有这些不同性质的氨解酶进行综述。这是一类催化相对直接的脱氨反应的酶。然而，这类酶具有多种不同的结构，利用多种不同的辅因子，并似乎通过一系列不同的机制催化这一相关反应。这篇综述的目的是解决一个基本问题:如果没有特定的蛋白质结构和活性位点结构，既需要又足以定义一个特定化学反应的催化剂，那么哪些因素决定了被选择来催化特定反应的结构和机制?

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来源期刊

Critical Reviews in Biochemistry and Molecular Biology 生物-生化与分子生物学

CiteScore

14.90

自引率

0.00%

发文量

期刊介绍： As the discipline of biochemistry and molecular biology have greatly advanced in the last quarter century, significant contributions have been made towards the advancement of general medicine, genetics, immunology, developmental biology, and biophysics. Investigators in a wide range of disciplines increasingly require an appreciation of the significance of current biochemical and molecular biology advances while, members of the biochemical and molecular biology community itself seek concise information on advances in areas remote from their own specialties. Critical Reviews in Biochemistry and Molecular Biology believes that well-written review articles prove an effective device for the integration and meaningful comprehension of vast, often contradictory, literature. Review articles also provide an opportunity for creative scholarship by synthesizing known facts, fruitful hypotheses, and new concepts. Accordingly, Critical Reviews in Biochemistry and Molecular Biology publishes high-quality reviews that organize, evaluate, and present the current status of high-impact, current issues in the area of biochemistry and molecular biology. Topics are selected on the advice of an advisory board of outstanding scientists, who also suggest authors of special competence. The topics chosen are sufficiently broad to interest a wide audience of readers, yet focused enough to be within the competence of a single author. Authors are chosen based on their activity in the field and their proven ability to produce a well-written publication.