Taking a look on fungi in cystic fibrosis: More questions than answers

IF 1.5 4区 生物学 Q4 MYCOLOGY Revista Iberoamericana De Micologia Pub Date : 2020-01-01 DOI:10.1016/j.riam.2019.10.004
M. Teresa Martín-Gómez
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引用次数: 6

Abstract

Cystic fibrosis (CF) is one of the most frequent recessive inherited diseases in western countries. Advances in medical care have led to a substantial increase in the life expectancy of CF patients. Survival beyond adolescence has permitted to see fungi not only as late colonizers, but also as potential pathogens responsible of allergic reactions and chronic infections related to lung function deterioration. The role of fungi, nevertheless, has been overlooked until recently. As a result, a number of questions on their epidemiology, clinical significance, or diagnosis, among others, remain unanswered. Besides more in depth studies about the extent of the deleterious effect of fungi on the CF host, new technologies may provide the key to understand its pathogenic role, its interaction with other microbial components of the respiratory microbiota, and should pave the way to define subsets of patients at risk who would benefit from specific therapy. This review is intended to provide a quick overview on what we know about the presence of fungi in the CF airway and its repercussion in the host, and to point out some of the many knowledge gaps needed to understand and advance in the management of fungi in the airway of CF subjects.

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看看真菌在囊性纤维化中的作用:问题多于答案
囊性纤维化(CF)是西方最常见的隐性遗传性疾病之一。医疗保健的进步使CF患者的预期寿命大大延长。存活到青春期之后,真菌不仅是晚期的殖民者,而且是导致过敏反应和与肺功能恶化相关的慢性感染的潜在病原体。然而,真菌的作用直到最近才被人们所忽视。因此,关于其流行病学、临床意义或诊断等方面的许多问题仍未得到解答。除了对真菌对CF宿主的有害影响程度进行更深入的研究外,新技术可能为了解其致病作用及其与呼吸微生物群中其他微生物组分的相互作用提供关键,并为确定高危患者亚群并从特定治疗中受益铺平道路。本文旨在对真菌在CF气道中的存在及其对宿主的影响进行快速概述,并指出一些需要了解和推进CF受试者气道真菌管理的许多知识空白。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.90
自引率
0.00%
发文量
17
审稿时长
81 days
期刊介绍: Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.
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