The Evolving Field of Stereotactic Body Radiation Therapy in Pancreatic Cancer.

Pancreas (Fairfax, Va.) Pub Date : 2019-01-01 Epub Date: 2019-11-06 DOI:10.17140/POJ-3-110
Maged Ghaly, Emile Gogineni, Muhammad W Saif
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引用次数: 13

Abstract

Pancreatic cancer remains a devastating disease with dismal outcomes despite the development of novel chemotherapeutic regimens and radiation techniques. Stereotactic body radiation therapy (SBRT) offers an advantage both in image guidance and radiation dose delivery to direct ablative doses to tumors with acceptable toxicity compared to conventional techniques. Recent literature is clustered with data pertaining to SBRT in patients with resectable, borderline resectable and locally advanced pancreatic tumors. We here present a summary of the current data and highlight the limitations and potential for future growth. Further clinical study in the form of multi-institutional trials is warranted to establish the role of SBRT in combination with new chemo- therapeutic agents as well as a non-invasive alternative to surgery.

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胰腺癌立体定向放射治疗领域的发展。
尽管有新的化疗方案和放疗技术的发展,胰腺癌仍然是一种毁灭性的疾病,其结果令人沮丧。与传统技术相比,立体定向全身放射治疗(SBRT)在图像引导和辐射剂量传递方面具有优势,可直接消融剂量到肿瘤,毒性可接受。最近的文献集中了关于SBRT在可切除、交界性可切除和局部晚期胰腺肿瘤患者中的应用。我们在此总结当前数据,并强调其局限性和未来增长的潜力。多机构试验形式的进一步临床研究是必要的,以确定SBRT与新的化疗药物联合使用的作用,以及一种非侵入性的手术替代方案。
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Outstanding Outcome of Pancreatic Cancer: What Lessons Do We Learn. Outstanding Outcome of Pancreatic Cancer: What Lessons Do We Learn The Evolving Field of Stereotactic Body Radiation Therapy in Pancreatic Cancer. Why HALO 301 Failed and Implications for Treatment of Pancreatic Cancer. PARP Inhibitors in Pancreatic Cancer: From Phase I to Plenary Session.
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