In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice.

IF 3.4 Q2 BIOCHEMICAL RESEARCH METHODS Biochemistry Research International Pub Date : 2020-01-22 eCollection Date: 2020-01-01 DOI:10.1155/2020/9749410

Hana Biruk, Biruk Sentayehu, Yonatan Alebachew, Wondmagegn Tamiru, Abebe Ejigu, Solomon Assefa

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Abstract

Background: Despite a substantial scientific progress over the past two decades, malaria continues to be a worldwide burden. Evergrowing resistance towards the currently available antimalarial drugs is a challenge to combat malaria. Medicinal plants are a promising source of new drugs to tackle this problem. Thus, the present study aimed at evaluating the antiplasmodial activity of Terminalia brownii in Plasmodium berghei infected mice.

Methods: A 4-day suppressive test was employed to evaluate the antimalarial effect of 80% methanol and aqueous bark extracts of T. brownii against P. berghei in Swiss albino mice.

Results: The in vivo acute toxicity test indicated that both extracts of T. brownii against p < 0.001) compared to negative control. The maximum level of chemosuppression (60.2%) was exhibited at 400 mg/kg dose of 80% methanol extract. Moreover, the 80% methanol extract showed a significant (p < 0.001) compared to negative control. The maximum level of chemosuppression (60.2%) was exhibited at 400 mg/kg dose of 80% methanol extract. Moreover, the 80% methanol extract showed a significant (.

Conclusion: The present study indicated that hydromethanolic and aqueous bark extracts of T. brownii possess a promising antimalarial activity, with higher effect exhibited by the hydromethanolic extract.T. brownii against.

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80% 甲醇和水树皮提取物对小鼠体内贝氏疟原虫的抗疟活性。(Combretaceae) 对小鼠疟原虫的抗疟活性。

背景：尽管在过去二十年中取得了巨大的科学进步，疟疾仍然是全世界的负担。对现有抗疟药物的抗药性不断增加是抗击疟疾的一大挑战。药用植物是有希望解决这一问题的新药来源。因此，本研究旨在评估棕毛姬鼠疟原虫感染小鼠的抗疟活性：方法：采用为期 4 天的抑制试验来评估 80% 甲醇和水树皮提取物对瑞士白化小鼠中伯格氏疟原虫的抗疟效果：体内急性毒性试验结果表明，与阴性对照组相比，棕色树皮的两种提取物都有抗疟作用（p < 0.001）。80% 甲醇提取物的剂量为 400 毫克/千克时，化学抑制水平最高（60.2%）。此外，与阴性对照组相比，80% 甲醇提取物的化学抑制效果显著（p < 0.001）。当 80% 甲醇提取物的剂量为 400 毫克/千克时，其化学抑制作用达到最大值（60.2%）。此外，80% 的甲醇提取物也显示出了显著的化学抑制作用（......）：本研究表明，褐飞虱的水乙醇提取物和树皮水提取物具有良好的抗疟活性，其中水乙醇提取物对褐飞虱的抗疟活性更高。

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