No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake.

IF 2.1 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2019-07-01 DOI:10.1177/1470320319874615
Sigurdur T Sigurdsson, Peter Bie, Arne H Nielsen, Svend Strandgaard, Olaf B Paulson
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Abstract

Autoregulation of cerebral blood flow (CBF) denotes that CBF is constant despite fluctuation of blood pressure within wide limits. Inhibition of the renin-angiotensin system (RAS) is known to decrease the lower and upper limits of CBF autoregulation. We have previously shown that this includes inhibition by the angiotensin receptor blocker (ARB) candesartan. In the present study we investigated the influence of the ARB candesartan on the lower limit of CBF autoregulation in two groups of Sprague-Dawley rats, on high (4.0% Na+) and low (0.004% Na+) sodium diet, respectively. Control animals were given the same diet, but no ARB. CBF was studied with the laser Doppler method. Blood pressure was lowered by controlled bleeding. Results revealed that both high and low sodium diet with low and high renin levels respectively block the influence of candesartan on CBF autoregulation. This was expected in rats on a high salt diet with a low renin level, but unexpected in rats with a low salt intake with a high renin level.

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血管紧张素受体阻滞剂坎地沙坦对高钠和低钠大鼠脑血管自动调节无影响。
脑血流的自动调节(CBF)表明,尽管血压在很大范围内波动,但CBF是恒定的。已知抑制肾素-血管紧张素系统(RAS)可降低CBF自动调节的下限和上限。我们之前的研究表明,这包括血管紧张素受体阻滞剂坎地沙坦的抑制作用。在本研究中,我们研究了ARB坎地沙坦对两组高钠(4.0% Na+)和低钠(0.004% Na+)饮食的Sprague-Dawley大鼠CBF自动调节下限的影响。对照组动物给予相同的饮食,但不给予ARB。用激光多普勒法研究脑血流。控制出血降低了血压。结果表明,高钠和低钠饮食、低肾素和高肾素水平分别阻断坎地沙坦对CBF自动调节的影响。这在高盐饮食和低肾素水平的大鼠中是意料之中的,但在低盐饮食和高肾素水平的大鼠中却出乎意料。
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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
16
审稿时长
6-12 weeks
期刊介绍: JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.
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