MTT assay dataset of polyethylenimine coated graphenoxide nanosheets on breast cancer cell lines (MCF7, MDA-MB-231, MDA-MB-468).

Q3 Medicine Human Antibodies Pub Date : 2020-01-01 DOI:10.3233/HAB-200407
Parichehr Maleki, Zahra Sadeghi, Sayyed Shahryar Rahpeyma, Mohammad Taheri, Jamshid Raheb
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引用次数: 6

Abstract

Graphen oxide has emerged as a promising tool in medical biotechnology due to its outstanding properties applicable in several fields as well as cell imaging, drug and gene delivery. Monolayer structure and high surface area of Graphen benefits elevated loading capacity of drugs rather than other nanomaterials. However Graphen oxide in physiological solutions has unfavourable reactions which confine it's application in biomedical field without additional surface functionalization. Coating of graphenoxide by polyethylenimine is an approach to enhance biocompatibility of graphen oxide and also provides desirable physicochemical features for oligonucleotides delivery. The data presented here is related to graphenoxide-PEI characterisation and it's cytotoxicity assay on variouse breast cancer cell lines including MDA-MB-468 and MDA-MB-231 and MCF7 by MTT assay.

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乳腺癌细胞系(MCF7, MDA-MB-231, MDA-MB-468)上聚乙烯亚胺包被氧化石墨烯纳米片的MTT分析数据集
氧化石墨烯因其优异的性能在细胞成像、药物和基因传递等多个领域的应用而成为医学生物技术中很有前途的工具。与其他纳米材料相比,石墨烯的单层结构和高表面积有利于提高药物的负载能力。然而,氧化石墨烯在生理溶液中的不良反应限制了其在生物医学领域的应用。聚乙烯亚胺包覆氧化石墨烯是一种提高氧化石墨烯生物相容性的方法,同时也为寡核苷酸的递送提供了理想的物理化学特性。这里提供的数据与石墨烯- pei表征及其对多种乳腺癌细胞系(包括MDA-MB-468、MDA-MB-231和MCF7)的细胞毒性测定有关。
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来源期刊
Human Antibodies
Human Antibodies Medicine-Immunology and Allergy
CiteScore
3.50
自引率
0.00%
发文量
27
期刊介绍: Human Antibodies is an international journal designed to bring together all aspects of human hybridomas and antibody technology under a single, cohesive theme. This includes fundamental research, applied science and clinical applications. Emphasis in the published articles is on antisera, monoclonal antibodies, fusion partners, EBV transformation, transfections, in vitro immunization, defined antigens, tissue reactivity, scale-up production, chimeric antibodies, autoimmunity, natural antibodies/immune response, anti-idiotypes, and hybridomas secreting interesting growth factors. Immunoregulatory molecules, including T cell hybridomas, will also be featured.
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